Investigating the Impact of Nudging Cardiologists to Prescribe Guideline-directed Medical Therapy in Heart Failure Patients

Assessment of Digital Care on Clinical Impact and Efficiency Using a Stepped Wedge Cluster RCT in Heart Failure Patients: the ADMINISTER II Trial

Status

Enrolling by invitation

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06844006

Acronym

ADMINISTER II

Enrollment

1320

Registered

2025-02-25

Start date

2024-06-13

Completion date

2028-08-31

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

Digitial Care, Home monitoring, Heart Failure, Nudging

Brief summary

This study investigates the impact of a nudge-based intervention on improving guideline directed medical therapy (GDMT) prescription among cardiologists. Using a stepped wedge randomized controlled trial design, we assess whether digital decision support-leveraging home monitoring and clinical data-enhances adherence to guideline-recommended medication titration. The primary outcomes include HF related hospitalization rates and all cause mortality.

Interventions

COMBINATION_PRODUCTNudging

Clinicians will be nudged with a prompt, based on remote monitoring data, current medication data, contraindications, in the electronic patient dossier whether further optimization to guideline directed medical therapy (GDMT) is possible.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Stepped Wedge Randomized Controlled Trial.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All heart failure diagnoses * \>18 years

Exclusion criteria

* Not understanding the Dutch Language. * Allergies that make uptitration impossible. * Admission to hospice or palliative care. * Severe psychological disorders.

Design outcomes

Primary

Measure	Time frame	Description
HF related hospitalization	From enrollment to the end of the design (15 months).	The frequency of HF related hospitalization and duration of the hospitalization.
All cause death	All cause death rate during the 15 month duration of the study.	—

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 11, 2026