Executive Dysfunction, Mild Cognitive Impairment (MCI)
Conditions
Keywords
Feasibility study, Mixed reality, Mild cognitive impairment, Executive Dysfunction
Brief summary
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level. Previous studies found that exercise can prevent executive and physical dysfunctions for people with MCI. However, the motivation is a critical factor in supporting a sustainable exercise. Exergame is combination of exercise and video game. Enjoyment during playing an exergame can support the exercise motivation. Therefore, we will explore the feasibility of using MR exergame in people with MCI.
Interventions
OTHERMixed reality exergame
The participants will play the Balloon Popping game using Hololens2 (Mixed reality glasses) for one hour. The objective of this game will be to pop all the virtual balloons, focusing on training different executive functions such as inhibitory control and cognitive flexibility. When a participant raises a finger in the air, a virtual needle will appear. After that, the participant will move their finger towards a balloon. Successful contact with a balloon will be indicated by the sound of a pop and the visual effect of confetti.
OTHEREducation
The participants will seat on a chair and watch video clip about MCI and dementia for one hour.
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy group: 1) MoCA score \> 24; 2) Independent walking without using gait aids; 3) No diagnosis of the dementia by clinician. * MCI group: 1) MoCA score between 16 to 24; 2) Independent walking without using gait aids.
Exclusion criteria
* Uncontrolled high blood pressure (more than 140/90 mmHg) * Hemodialysis * Have clinical diagnosis of the disease or symptoms that could influence the performance assessments such as arthritis or severe hand pain which reports by participants and the testing by physiotherapist before testing. * History of neurological disorder, such as stroke or other neurodegenerative disorder * Taking medicine which affected to functional movement. * Unable to follow study protocol. * Uncorrected visual or hearing impairment. * Positive screening for contraindication of TMS which will be confirmed by TMS screening questionnaire such as uncontrolled seizures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual attention and task switching | before and immediately after intervention | Trail Making Test |
| Inhibitory control | before and immediately after intervention | Color-Word Stroop Test |
| Single-task performance | before and immediately after intervention | Box and Block Test |
| Dual-task performance | before and immediately after intervention | Box and Block with Serial Sevens Test |
| Cortical outcomes | before and immediately after intervention | Transcranial magnetic stimulation was used for measuring the cortical outcomes, which consist of resting motor threshold, input-output curve of motor evoked potentials recruitment and cortical silent period. |
| Usability | immediately after Mixed reality exergaming | System usability scale questionnaire was used for measuring the usability of mixed reality exergame. It consists of 10-item, which are typically rated on a five-point scale. A higher SUS score generally indicates better usability. |
| Motivation | immediately after Mixed reality exergaming | Intrinsic Motivation Inventory was used for measuring the motivation. It rated on seven-point scale. Higher IMI scores reflect higher levels of motivation. |
| Adverse side effects | immediately after Mixed reality exergaming | Cybersickness in Virtual Reality Questionnaire was used for assessing cybersickness symptoms, including nausea, vestibular, and oculomotor. The total score is the sum of the three sub-scores. Each question is presented on a 7-item Likert Scale. |
Countries
Thailand
Outcome results
None listed