Immediate Implant Placement
Conditions
Keywords
Hyaluronic acid, Vitamin D, Xenograft, Immediate Implant
Brief summary
Immediate implant placement using xenograft as space filling material mixed with vitamin D versus hyaluronic acid in posterior mandible region This study aims to evaluate implant stability and density after placement of immediate implant and Xenograft mixed with Hyaluronic acid or Vitamin D at posterior mandible region
Detailed description
Dental implants in fresh extraction sockets and healed sites have a erratic morphology, creating a wide space defect between the implant and buccal alveolar bone. This defect is critical for implant success, known as a jumping gap. Proper management of this space is essential for esthetic and functional success. Studies show adequate bone fill can be achieved in jumping gaps, but wider gaps increase implant body exposure risk. The application of biological mediators embedded in the biomaterial can induce specific cell and tissue response, which can improve bone quality and quantity. Dental research has focused on improving bone substitutes by morphologic or bio- chemical modification.
Interventions
PROCEDUREHyaluronic Acid (HA)
Hyaluronic acid is one of the essential components of extracellular matrix, which plays a predominant role in tissue morphogenesis, cell migration, differentiation, and adhesion. It has been recently reported that hyaluronic acid increases osteoblastic bone formation in vitro through increased mesenchymal cell differentiation and migration. It has demonstrated that Hyaluronic acid not only acted as a carrier of growth factors and cell but also stimulated bone formation through chemotaxis, proliferation and differentiation of mesenchymal cells into osteoblasts. Although Hyaluronic acid shares bone induction properties with growth factors as bone morphogenic protein 2 and osteopontin
PROCEDUREVitamin D
It was shown that locally applied vitamin D3 in combination with bovine bone mineral matrix improved the bone formation and strengthened the site of the fracture in ovariectomized rats. Local application of vitamin D3 also proved to be promising in promoting osteo- genesis and mineralization for restoration of bone defects. Grounding on this incites, it has been suggested that vitamin D3 might exert a positive local effect on alveolar bone regeneration
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Each patient will be given a code by the researcher and the observers will be blind to which group this case belong. Patients, radiographic outcome assessor and statistician will be blinded.
Intervention model description
Randomized Controlled Clinical Trial. Parallel group study. Allocation Ratio 1:1.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Age: 18-60. * Systemically healthy patients indicated for single or multiple immediate implants in posterior teeth region. * Absence of any peri-apical pathosis. * Patients with intact buccal plate of bone. * Patients with adequate bone volume for the dental implant procedure. * Patient with good oral hygrine
Exclusion criteria
* Heavy Smokers. * Systemic disease that may affect the final outcome of the surgical procedure. * No or poor patient's compliance. * Patients with psychological problems. * Pathology at the site of intervention. * Patient with vit d deficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implant secondary stability | after 6 months | To evaluate the implant stability by Any-check device. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Density of bone around implant | after 6 months | Cone beam computed tomography CBCT |
Countries
Egypt
Contacts
Primary ContactAMMAR EIZ EDDIN
Backup ContactMOHAMED ASHRAF, phD
Outcome results
None listed