Role of Corneal Nerves in Dry Eye Disease

Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06841471

Enrollment

140

Registered

2025-02-24

Start date

2025-02-20

Completion date

2025-12-31

Last updated

2025-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Nerve, Dry Eye, Dry Eye Disease (DED), Dry Eye Sensation

Brief summary

This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss. Additionally, it seeks to investigate whether these factors vary based on the severity of dry eye symptoms.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Group with DED: Diagnosis of DED based on the TFOS DEWS II report * Group without DED: No diagnosis of DED

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Differences of corneal nerve function and morphology in relation with DED signs	within one week	Correlation coefficient between corneal sensitivity and corneal nerve morphology, and variables related to tear film stability and corneal surface homeostasis.

Secondary

Measure	Time frame	Description
Differences of corneal nerve function and morphology in relation with DED symptoms	within one week	Correlation coefficient between corneal sensitivity, corneal nerve morphology, and the severity of dry eye symptoms.

Countries

Switzerland

Contacts

Primary ContactDaniela S Nosch, BSc MSc PhD

daniela.nosch@fhnw.ch41629572603

Backup ContactEmanuele Käser, BSc MSc

emanuele.kaeser@fhnw.ch41629572302

Outcome results