Corneal Epithelial Wound Healing
Conditions
Brief summary
Data analyses and revision of the corneal re-epithelization in patients who underwent either PRK (Photorefractive Keratectomy), CXL (Corneal Cross-Linking), PTK (phototherapeutic keratectomy), or experienced a corneal abrasion. A novel ophthalmic solution containing cross-linked CMC (CX-CMC) and Silk Proteins (SP) has been made available on the market. Both molecules have been widely studied for their wound healing properties in the ophtalmic field. This new ophthalmic solution is the first on the market formulated with a CX-CMC and SP.
Interventions
DEVICECTRL
Standard therapy plus sterile ophtalmic isotonic solution for six time a day until complete healing.
DEVICECXC-SP
Standard therapy plus sterile Isotonic ophthalmic solution based on CX-CMC and silk protein, istilled six time a day until complete healing.
Sponsors
San Giovanni Addolorata Hospital
D&V FARMA srl
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who had undergone surgical procedures involving de-epithelialization, which included CXL, PRK, and PTK, as well as those with a first diagnosis of corneal abrasion
Exclusion criteria
* patients with known allergies or hypersensitivity to any components of the tested formulations or standard therapies, or those requiring different treatments compared to the rest of the study population
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Corneal re-ephitalization | 2 WEEKS | To evaluate and follow the corneal re-ephitalization process a topograph measuring epithelium thickness will be used. |
Countries
Italy
Outcome results
None listed