Skip to content

Caries-associated Saliva Biomarkers Among Different Races

Caries-associated Saliva Biomarkers in Caries Experienced and Caries Free Population Among Different Races: Diagnostic Accuracy Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06838182
Enrollment
22
Registered
2025-02-20
Start date
2025-02-25
Completion date
2025-04-25
Last updated
2025-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries,Dental

Brief summary

discover possible differences and develop effective preventative interventions by examining the relationship between salivary biomarkers and caries prevalence across different racial groups and Detect risk factors involved in caries incidence .

Detailed description

Dental caries is a multifactorial condition that is influenced by both external and internal variables. Tooth decay progression is directly influenced by host factors, including the individual's immune competence, saliva flow rate and buffering capacity, tooth form, and bacterial makeup . While salivary biomarkers are essential for predicting the risk of dental caries, little is known about how they relate to caries in a variety of populations. By examining the relationship between salivary biomarkers and caries prevalence across several racial groups, this study seeks to close this gap and enhance culturally appropriate preventive approaches . There have been contentious discussions over the causes of differences in oral health during the past forty years. The term structural inequities refers to the social, environmental, economic, and cultural determinants of health, which are frequently impacted by racial or ethnic background, gender, work status, immigrant status, and geographic location. Racialized populations have demonstrated greater rates of untreated dental decay (caries), severe periodontal disease, and total or partial edentulism . Typically, race refers to an individual's physical characteristics, such as skin tone or hair type, which may indicate their ancestry. White, African American, or Asian descent are some examples of classifications that are frequently used to characterize race .

Interventions

DIAGNOSTIC_TESTSalivary biomarkers tests

saliva samples are collected from participants

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

* Age : 19-25 * We will have 2 groups according to ICDAS classification : Not severe (ICDAS score ≤3) / Severe (ICDAS score ≥3)

Exclusion criteria

* : Those who reported daily use of alcohol or tobacco . * Those who used antibiotics or other systemic drugs within the previous three months . * Those who regularly used antiseptics

Design outcomes

Primary

MeasureTime frameDescription
the patient has caries or not according to ELISA and colorimetric assay3 monthsChange in concentration of salivary PRP( proline rich proteins) levels (ng\\ml )

Contacts

Primary ContactFatma ahmed al safy, Master degree
fatomalsafy@gmai.com00201145084182
Backup Contactshereen hafez ibrahim, phd
shereen.hafez@dentistry.cu.edu.eg01099296591

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026