Hemiplegia Due to Stroke, Parkinson Disease, Parkinsonian Syndrome
Conditions
Keywords
Rhythmic auditory stimulation, Hemiplegia after stroke, Parkinsonism syndrome, Gait disorders, Parkinson disease
Brief summary
The aim of this clinical trial was to determine whether rhythmic auditory stimulation is effective in treating gait disorders in patients with post-stroke hemiplegia, primary Parkinson's disease, and various parkinsonism syndromes. The main questions it aims to answer are: Does rhythmic auditory stimulation increase walking speed in patients with gait disorders? To determine whether rhythmic auditory stimulation is effective in treating gait disorders, researchers will compare a gait rhythmometer with an active control that does not receive rhythmic stimulation. Participants will: Gait training was conducted once a day for 15 minutes for 7 consecutive days Resting-state functional magnetic resonance imaging (fmri) was performed before and after treatment Feedback on subjective improvement at the end of the 7-day treatment
Interventions
The intervention group was treated with a gait rhythm device under the supervision of the researchers. The complete gait training was conducted once a day for 15 minutes for 7 consecutive days. Each patient wore inertial sensors at both ankles during gait training to collect gait information during walking.
DEVICENo rhythm stimulation
The control group received gait training without rhythmic auditory stimulation under the supervision of the researchers. The complete gait training was conducted once a day for 15 to 20 minutes for 7 consecutive days. Each patient wore inertial sensors at both ankles during gait training to collect gait information during walking.
Sponsors
YiCheng Zhu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
For post-stroke hemiplegia Inclusion criteria : * Age 50-80 years old * One or more strokes (cerebral infarction or cerebral hemorrhage), with the most recent stroke occurring at least 6 months earlier * Walking independently without a cane or walking aid with obvious gait asymmetry * 0.4m/s\< baseline velocity \<0.8m/s * Sufficient hearing, vision and comprehension to complete motor function tests * Patients were willing and able to participate in all study procedures and signed informed consent * No other rehabilitation treatment was received at present
Exclusion criteria
* Unable to cooperate with the motor function test * Uncontrolled hypertension * Myocardial infarction within the past 3 months * With bone and joint diseases, such as a history of lower limb fracture within 1 year, waist and lower limb bone and joint surgery, bone and joint deformity seriously affecting walking, etc. * Except for stroke, there was no parkinsonism, myasthenia gravis, poliomyelitis and other nervous system diseases affecting the walking function of patients. For primary Parkinson's disease (PD) Inclusion criteria: * Age 50-80 years old * PD met the diagnostic criteria of Chinese Diagnostic Criteria for Parkinson's Disease (2016 edition) * Obvious panic gait, freezing gait or slow gait, but can walk independently without the use of a cane or walking aid * Hoehn-Yahr (H-Y) stage 2-4 * 0.4m/s\< baseline velocity \<0.8m/s * Sufficient hearing, vision and comprehension to complete motor function tests * Patients were willing and able to participate in all study procedures and signed informed consent * No other rehabilitation treatment was received at present
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gait speed | 10 days | The difference between the gait speed measured on the third day after the completion of the seven gait sessions and the baseline gait speed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stride frequency | 10 days | The difference between the stride frequency (left and right) measured on the third day after the completion of the seven gait sessions and the baseline stride frequency. |
| Stride speed | 10 days | The difference between the stride speed (left and right) measured on the third day after the completion of the seven gait sessions and the baseline stride speed. |
| Swing speed | 10 days | The difference between the swing speed (left and right) measured on the third day after the completion of the seven gait sessions and the baseline swing speed. |
| Stride length | 10 days | The difference between the stride length (left and right) measured on the third day after the completion of the seven gait sessions and the baseline stride length. |
| Turn time | 10 days | The difference between the turn time measured on the third day after the completion of the seven gait sessions and the baseline turn time. |
| Patient's SUBJECTIVE assessment | 10 days | All subjects were asked about their subjective feelings using a uniform questionnaire, including the following questions: Did the patient's gait problems improve after 7 days of treatment? If there has been improvement, in what ways? (Step speed, stride length, symmetry, turn time, etc.) |
| Resting-state functional magnetic resonance imaging | 10 days | At baseline and on the third day after completion of the 7-day gait treatment, 3T resting-state functional magnetic resonance imaging (rs-fMRI) was performed to compare the changes of local neural activity, including amplitude of low frequency fluctuation (ALFF) and functional connectivity density (FCD). |
| Standing phase | 10 days | The difference between the standing phase (left and right) measured on the third day after the completion of the seven gait sessions and the baseline standing phase. |
Countries
China
Outcome results
None listed