Neuropsychology, Outcome, Seizure, Epileptic
Conditions
Keywords
First epileptic seizure, Definition of epilepsy, Neuropsychology, outcome
Brief summary
The present study is a prospective study on the development of seizure frequency, medication adherence, quality of life and cognitive performance after a first epileptic seizure using the new diagnostic criteria for epilepsy of the International League Against Epilepsy of 2014 at the time of diagnosis.
Detailed description
The new diagnostic criteria for epilepsy, which have been in place since 2014, suggest that due to the improved possibilities for early diagnosis and treatment - particularly as a result of improved imaging diagnostics - changes in the incidence rates and severity of the course of epilepsies with different etiologies can be expected. The group of epilepsies with unclear etiology should now be smaller than in previous studies. The MRI- and EEG-positive patients can now be identified as having structural epilepsy based on the type of lesion, which was not possible in previous studies without differentiated imaging. The fact that these patients can now be treated before a patients can now be treated before a second seizure, the risk of recurrence and the health economic costs should also be reduced and have a positive effect on maintaining cognitive performance and quality of life after a first epileptic seizure. The aim of the study is to record the consequences of the new epilepsy diagnostic criteria in terms of outcome and treatment. In addition, the investigators will use a questionnaire battery and neuropsychological testing to record the potential neuropsychological deficits, financial and socio-medical consequences of a first seizure or early-stage epilepsy.
Interventions
None listed
Sponsors
University Hospital Marburg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Completion of the 18th year of life * first epileptic seizure * Ability to understand the patient information and to give written consent * Written consent for voluntary participation in the study
Exclusion criteria
* Chronic drug or alcohol abuse in the last two years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of seizure recurrency | 10 Years | Seizure recurrency is recorded 6 months, 1 year, 3 years, 5 years and 10 years after the first seizure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Salary | 10 years | Gross salary in Euro at the first attack, after 6 months, 1, 3, 5 and 10 years. |
| Driving restriction | 10 Years | Fitness to drive (yes/no) is assessed after the first attack, after 6 months, 1, 3, 5 and 10 years. |
| Verbale Lern- und Merkfähigkeitstest | 10 years | Verbale Lern- und Merkfähigkeitstest - VLMT (Helmstaedter, Lendt, & Lux, 2001) at baseline and then after 1 years, 5 years and 10 years after the first seizure: 0 to 135 points, O worst, 135 best possible result. |
| Regensburger Wortflüssigkeits-Test | 10 Years | Regensburger Wortflüssigkeits-Test - RWT (Aschenbrenner, Tucha, & Lange, 2000) at baseline and then after 1 years, 5 years and 10 years after the first seizure: Number of words starting with one asked letter, that can be said in 2 minutes (typically between 0 and 50) |
| employment | 10 years | Currently working as employee or independent, retirement or long-time sick-leave at the first attack, after 6 months, 1, 3, 5 and 10 years. |
| Trailmaking Test A & B | 10 Years | Trailmaking Test A & B (Tombaugh, 2004) at baseline and then after 1 years, 5 years and 10 years after the first seizure: individual time to absolve the test in seconds |
| Wechsler Adult Intelligence Scale - WAIS IV | 10 Years | Wechsler Adult Intelligence Scale - WAIS IV at baseline and then after 1 years, 5 years and 10 years after the first seizure: Intelligence quotient (40 to 160) |
| TAP | 10 Years | Test for Attentional Performance - TAP (Zimmermann & Fimm, 2002) at baseline and then after 1 years, 5 years and 10 years after the first seizure: reaction time in ms, standard deviation of the reaction time, ratio of errors ratio of correct reactions |
| Relationsship status | 10 years | Relationship status (single, maried, divorced) is assessed after the first attack, after 6 months, 1, 3, 5 and 10 years. |
| Copy and recall of the Rey-Osterrieth Figure | 10 Years | Copy and recall of the Rey-Osterrieth Figure (Berry, Allen, & Schmitt, 1991) at baseline and then after 1 years, 5 years and 10 years after the first seizure: 0 to 36 points. 0 worst possible result, 36 best possible result. |
Countries
Germany
Outcome results
None listed