Asthma Bronchiale
Conditions
Keywords
Asthma
Brief summary
The objective of this study is to detect the acoustic signals generated by the respiratory system on asthma patients using an acoustic sensor and retrospectively use these signals to identify the characteristics that differentiate patients with asthma and healthy subjects.
Detailed description
The objective of this project is to detect acoustic signals generated by the respiratory system in patients with asthma using the acoustic sensor; and then, retrospectively, to use these signals to carry out signal processing research, with the aim of trying to identify signal characteristics that can be used to differentiate asthma patients from people who do not have the disease. The hypothesis, therefore, is that it is possible to target through external smart bioelectronic devices and wireless connectivity (wearables) the initial signals of the pathophysiology of bronchial asthma and differentiate them from the signals of the normal respiratory physiology of a healthy individual. Similarly, detection of such signals would not only be useful for asthma diagnosis but also for monitoring and early detection of exacerbations before they can be detected by the usual respiratory functional tests. The patients will first visit the asthma unit where the diagnostic tests will be undertaken. Then the subjects will take the acoustic sensor home with them and wear it during sleep for at least two weeks.
Interventions
DIAGNOSTIC_TESTSpirometry test with bronchodilation
this test measures how much air you can breathe in and out of your lungs, as well as how easily and fast you can then blow the air out of your lungs
DIAGNOSTIC_TESTMethacholine challenge
test used to diagnose asthma where the patient breaths in methacholine
DIAGNOSTIC_TESTimpulse oscillometry
test that uses sound waves to measure how much resistance there is to the normal movement of air in and out of your lungs when you are breathing at rest
OTHERMeasurement of the exhaled FeNO fraction
Measure the level of nitric oxide in parts per billion (PPB) in the air the patient slowly exhales
Sponsors
Acurable Ltd.
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Male or female, aged \>= 18 and \< 65. * Ability to access applications on mobile device, technical understanding and minimal technological skills * Subject has provided informed consent and is willing to comply with the study procedures.
Exclusion criteria
* Subject does not consent to the study * Subject does not comply with inclusion criteria * Subject has a known allergy to medical adhesives
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acoustic respiratory signals | During the diagnostic tests performed and during the night studies performed by the participant for at least two weeks | Acoustic signals during the tests performed for asthma diagnosis and while the subjects sleep for at least two weeks. |
Countries
Spain
Contacts
Primary ContactOrsina Dessi
Outcome results
None listed