IPV and Lung Compliance in Invasively Ventilated Children

The Effect of Intrapulmonary Percussive Ventilation (IPV) on Lung Compliance in Critically Ill Pediatric Patients Requiring Invasive Mechanical Ventilation.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06836050

Enrollment

Registered

2025-02-20

Start date

2025-01-13

Completion date

2026-03-12

Last updated

2026-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Compliance, Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases

Keywords

Lung Compliance, Pediatric, Pediatric Acute Respiratory Distress Syndrome (PARDS), Intrapulmonary Percussive Ventilation (IPV)

Brief summary

The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation. The main questions it aims to answer are: 1. Does IPV improve lung compliance 15 minutes after and 3 hours after receiving one treatment in a heterogeneous group of pediatric patients? 2. Does IPV improve lung compliance in patients with Pediatric Acute Respiratory Distress Syndrome (PARDS), and what is the degree of change compared to those without PARDS? 3. What is the effect of IPV on lung compliance according to PARDS severity (mild-moderate disease vs. severe disease). 4. What is the incidence of adverse effects of IPV? Participants will receive IPV because their medical team feels it will help their lung recovery and has already determined them to be safe candidates to receive this therapy, which is a standard airway clearance modality already routinely used in our PICU. Nothing additional will happen to participants as a result of this study. Enrolling in this study simply gives the study team permission to collect specific health information that identifies your child for research purposes, which may include results from medical tests found in their medical record and information from your child's bedside monitor and ventilator. This information will be collected before and after the IPV treatments to evaluate their response to the therapy.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

0 Days to 18 Years

Healthy volunteers

Inclusion criteria

* ≤18 years old on conventional intermittent mandatory ventilation in the PICU that the physician deems is a candidate for IPV

Exclusion criteria

* The inability to accurately obtain ventilator measurements

Design outcomes

Primary

Measure	Time frame	Description
Dynamic Compliance	Baseline (15 minutes before IPV treatment), 15 minutes after IPV treatment, and 3 hours after IPV treatment	A measurement calculated and obtained from the patient's ventilator, averaged over 1 minute.

Secondary

Measure	Time frame	Description
Static Compliance (when applicable)	Baseline (15 minutes before IPV treatment), 15 minutes after IPV treatment, and 3 hours after IPV treatment	A measurement calculated and obtained from the patient's ventilator using an inspiratory hold maneuver.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORTodd Sweberg, MD

Northwell Health

Outcome results