Acute Kidney Injury
Conditions
Brief summary
ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment. Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).
Interventions
DIETARY_SUPPLEMENTAmino acid supplementation (Glavamin, Fresenius Kabi)
Mixture of amino acids (67 g / 500 ml) given intravenously
Sponsors
Karolinska University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Dialysis where amino acid supplementation is planned by treating physician
Exclusion criteria
* Liver failure * Muscle disease * Neurodegenerative disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Balance of amino acids | After 3 days of dialysis | Total balance of amino acid losses and supplementation given |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amino acid concentration in plasma | After 3 days of dialysis | Concentration of various amino acids in plasma without and with supplementation |
| Concentration of vitamins and trace elements | After 3 days of dialysis | Analysis of various trace elements and vitamins |
Countries
Sweden
Contacts
Primary ContactJonathan Grip, MD, PhD
Outcome results
None listed