Chronic Apical Periodontitis
Conditions
Keywords
chronic apical periodontitis, postoperative pain, N-asetil sistemin, chlorhexidin
Brief summary
The goal of this clinical study was to evaluate the effect of using different irrigation solutions in the final irrigation of root canal treatment procedures on the intensity of postoperative pain and periapical tissue healing in patients presenting with mandibular molars with chronic apical periodontitis. The main question it aims to answer is: \- Does controlled irrigation with chlorhexidin and N-asetil sistein in root canal treatment reduce the severity of postoperative pain? In the chlorhexidin group, unlike the control group, each root canal was irrigated with 3 mL %2 chlorhexidin solution in the final irrigation. In the N-asetil sistein group, unlike the control group, each root canal was irrigated with 3 mL 200 mg/ml N-asetil sistein solution in the final irrigation.
Interventions
DRUGN-Acetyl Cysteine
The root canals were irrigated with 3 mL N-acetyl Cysteine (NAC)(200 mg/ml) in N-acetyl Cysteine group in the final irrigation.
DRUGChlorhexidine
The root canals were irrigated with 3 ml %2 chlorhexidine in chlorhexidin group in the final irrigation.
Sponsors
Cukurova University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Mandibular permanent molars with chronic apical periodontitis * Teeth with periapical index (PAI) score greater than 2 * Teeth with periodontal pocket depth less than 3 mm * Patients without systemic disease (ASA 1-2)
Exclusion criteria
* Patients who have used analgesic, anti-inflammatory or opioid drugs in the last 7 days or antibiotics in the last 3 months * Patients who report pregnancy, lactation or psychiatric disorders * Teeth with a history of root canal treatment, sinus tract or abscess, and teeth planned for prosthetic restoration
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analogue Scale | up to 72 hours | The visual analog scale for pain is a straight line with one end meaning no pain (0) and the other end meaning the worst pain (10) imaginable. A patient marks a point on the line that matches the amount of pain he or she feels. It may be used to help choose the right dose of pain medicine. Also called VAS. |
Countries
Turkey (Türkiye)
Outcome results
None listed