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Intermittent Fasting vs. High-intensity Interval Training on the Lipid Profile of Obese Individuals.

Intermittent Fasting vs. High-Intensity Interval Training on Lipid Profile in Obese Patients

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06834256
Acronym
vs(versus)
Enrollment
80
Registered
2025-02-19
Start date
2023-07-01
Completion date
2024-05-01
Last updated
2025-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Intermittent Fasting,High-Intensity Training,,Obesity

Brief summary

we aimed to ascertain the effect of intermittent fasting (IF) vs. high-intensity interval training (HIIT) on the lipid profile and waist circumference (WC) of obese individuals.

Detailed description

Subjects and Methods: This study included 40 obese individuals of both genders aged 35-50 years with an abnormal lipid profile. The patients were allocated at random to either Group A or B, with both groups receiving medical treatment. Group A followed the IF regime, while Group B performed HIIT on the treadmill three times weekly, with an intervention duration of six weeks for both groups. Body mass index (BMI), WC, levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), alongside the Framingham risk score (FRS) were the evaluated variables.

Interventions

BEHAVIORALintermittent fasting

Group A participants followed the IF diet for 6 weeks . intermittent fasting , specifically time-restricted feeding (TRF), involves consuming all of one's energy requirements inside an 8-h.The fasting interval was designated as 16 h, and the other 8-h was the eating period . During the 8-h eating window, the patient consumes a well-balanced meal consisting of 55%-65% carbs, 7%-20% protein, and 15%-30% fat .

. Group B engaged in low-volume HIIT exercise (aerobic activity) three times weekly for six weeks. The exercise routine consisted of a 5-min warm-up phase at 70% of MHR, followed by four intervals of 2-min maximum effort cycling sessions (4 × 2 HIIT) compared to a sub-maximal workload at 85%-90% of MHR. The participants engaged in four work bouts, with each bout lasting around 4 min and followed by a 4-min rest period. During the workouts, the participants maintained an HR of 60%-70% of their MHR. This resulted in 8 min of intense physical activity during each training session. Additionally, there was a 5-min cooling down phase at 70% of the MHR. The treatment's intensity was adapted based on the modified Bruce protocol.

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
35 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

Inclusion criteria were as follows: (1) A BMI of 30 -40 kg/m2; (2) abnormal lipid profile, with a TC level \> 200 mg/dL, an LDL \> 100 mg/dL, a TC level \> 150 mg/dL, and an HDL \< 40 mg/dL; (3) steady vital signs, including blood pressure, respiration rate, and temperature at a baseline level.

Exclusion criteria

* The

Design outcomes

Primary

MeasureTime frameDescription
lipid profilelipid profile will be measured at baseline, and it will be measured again after six weeksA 5 mL fasting venous blood sample was collected following an eight-hour overnight fast, and LDL, HDL, TG, and TC levels were measured.

Secondary

MeasureTime frameDescription
waist circumferencewaist circumference will be measured at baseline, and it will be measured again after six weeksUtilizing tape measurements to measure WC.A WC \> 40 inches (102 cm) in males and \> 35 inches (88 cm) in women indicated an elevated risk for cardiometabolic disorders
The Framingham risk score (FRS)The Framingham risk score (FRS) will be measured at baseline, and it will be measured again after six weeksIt was employed to ascertain the cardiovascular disease risk over ten years.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026