Preoperative, Carbohydrate, Pediatric, Elective Surgery
Conditions
Brief summary
This work evaluated the systemic effect of different preoperative carbohydrate (CHO) loads in pediatrics undergoing elective surgery.
Detailed description
Children undergoing surgery experience stress due to disruptions in their daily routine and exposure to various perioperative circumstances that induce anxiety and pain. The management of perioperative nutrition in pediatric patients is a crucial aspect of patient care. The concept of preoperative carbohydrate (CHO) loading has gained attention as a potential strategy to mitigate these drawbacks. The administration of a CHO-rich drink two hours preoperative has been proposed to maintain euglycemia, decline IR, and enhance postoperative recovery
Interventions
OTHERApple juice
A preoperative carbohydrate load was done two hours before the operation using a10 ml/kg, with a maximal volume of 250 ml of commercial brand of apple juice (glucose 28 g in 250 ml).
A preoperative carbohydrate load was done using 1.75mg/kg/dose of anhydrous glucose (Alpha Chmika).
OTHERWater
Patients received water.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
5 Years to 10 Years
Healthy volunteers
No
Inclusion criteria
* Age from 5 to 10 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I and II. * Scheduled for elective surgery.
Exclusion criteria
* Diabetes mellitus. * Insulin resistance (IR). * Renal or hepatic insufficiency. * Esophageal or gastric surgery or gastrointestinal disorders history (including gastroesophageal reflux, hiatal hernia, or gastritis).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| C-reactive protein (CRP) level | 4 hours postoperatively | C-reactive protein (CRP) level was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of procalcitonin | 4 hours postoperatively | Level of procalcitonin was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. |
| Homeostatic model assessment for insulin resistance | 4 hours postoperatively | Homeostatic model assessment for insulin resistance(HOMA.IR) was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. |
| Level of C-peptide | 4 hours postoperatively | Level of C-peptide was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. |
| Neutrophil/ lymphocyte ratio | 4 hours postoperatively | Neutrophil/ lymphocyte ratio (NLR) was assessed 2 h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation. |
| Patient's parent's satisfaction | 4 hours postoperatively | Parent satisfaction level was evaluated by 3-point Likert scale (1, unsatisfied; 2, neutral; 3, satisfied). |
| Incidence of complications | 4 hours postoperatively | Incidence of complications such as perioperative nausea, vomiting, and aspiration were documented. |
| Level of random blood glucose | Two hours before the surgery | Level of random blood glucose (RBG) was measured at two hours before the surgery. |
Countries
Egypt
Outcome results
None listed