Nosocomial Infection
Conditions
Keywords
nosocmial infection, prophylaxis, garlic
Brief summary
The goal of this clinical trial is to learn if garlic tablets works to prevent nosocomial infections in hospitalized patients in ICU. The main questions it aims to answer are: Does garlic tablets administration lower the occurence of nosocomial infections in hospitalized patients in ICU?
Interventions
The intervention is the administration of garlic tablets (Tomex plus 300 mg) two tablets twice daily (which contains 5.4 mg allicin the active ingredient with anibacterial effect) for 6 days just after ICU admission
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
It is a randomized non blinded controlled trial. Eligible patients will be randomly divided into two groups: An intervention group which will receive garlic tablets (Tomex plus 300 mg) two tablets twice daily for 6 days just after ICU admission and a control group which will not receive the garlic tablets.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All patients aged from 18 to 65 years old admitted to intensive care units without any type of infection.
Exclusion criteria
1. Patients with signs /symptoms of infection. 2. Patients with human immunodeficiency virus, malignancy and patients with a history of recent immunosuppressants or corticosteroids administration. 3. Patients with bleeding disorders or abnormal coagulation profile 4. Patients who will planned for surgery within 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of central line-associated bloodstream infections, catheter- associated urinary tract infections, surgical site infections and ventilator- associated pneumonia in the two groups (by cultures results). | one year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Values of Blood white cell count, body temperature and C-reactive protein of the patient in the two groups . | one year | The Mean of Blood white cell count (number per micro liter) , body temperature ( by the degree Celsius) and C-reactive protein (milligrams per liter ) of the patients in the two groups will be calculated. |
Other
| Measure | Time frame |
|---|---|
| Antibiotics consumption as total number of vials per each antibiotic in the two groups. | one year |
| Lenghth of stay of patients in ICU (by average number of days) in the two groups | one year |
| Mortality rate of patients in the two groups | one year |
Countries
Egypt
Outcome results
None listed