Critical Care, Echocardiographic Software, Left Atrial Strain, Reproducibility, Right Atrial Strain, Septic Shock, Speckle Tracking, Transthoracic Echocardiography
Conditions
Keywords
transthoracic echocardiography, septic shock, left atrial strain, right atrial strain, speckle tracking, echocardiographic software, AutoStrain, Bland-Altman analysis, reproducibility, critical care
Brief summary
Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire, Amiens
Henri Mondor University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age: \>18 years * Adult patients admitted to critical care for septic shock (SEPSIS-3 definition) * TTE performed as part of medical management * No objection to data usage
Exclusion criteria
* Pregnancy * Moderate to severe valvular regurgitation/stenosis (\>grade 2) * Ventricular or supraventricular tachyarrhythmia (HR \>140 bpm) at the time of TTE * Poor echogenicity preventing LAS measurement * Mechanical circulatory support * Pacemaker dependence * Patients under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| variation of LASr between ECOPAC and UWS | 1 year | Agreement of LAS Reservoir Phase (LASr) measurement in manual mode between ECHOPAC and UWS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| variation of LAScd between ECHOPAC and UWS | 1 year | Comparison of LAS Conduit (LAScd) measurements in manual mode between ECHOPAC and UWS |
| variation of LASct between ECHOPAC and UWS | 1 year | Comparison of LAS Conduit (LAScd) and Contraction (LASct) measurements in manual mode between ECHOPAC and UWS |
| Comparison of LASr measurements in apical 2-chamber views | 1 year | Comparison of LASr measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS |
| Comparison of LAScd measurements in apical 2-chamber views | 1 year | Comparison of LAScd measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS |
| Comparison of LASct measurements in apical 2-chamber views | 1 year | Comparison of LASct measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS |
| Comparison of right atrial strain RASr between ECHOPAC and UWS | 1 year | Comparison of right atrial strain (RASr) in manual mode between ECHOPAC and UWS |
| Comparison of right atrial strain RAScd between ECHOPAC and UWS | 1 year | Comparison of right atrial strain RAScd in manual mode between ECHOPAC and UWS |
| Comparison of right atrial strain RASct between ECHOPAC and UWS | 1 year | Comparison of right atrial strain RASct in manual mode between ECHOPAC and UWS |
| Comparison of LAS in AutoStrain versus manual mode | 1 year | Comparison of LAS measurements in AutoStrain versus manual mode on UWS |
| Comparison of RAS in AutoStrain versus manual mode | 1 year | Comparison of RAS measurements in AutoStrain versus manual mode on UWS |
| Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC | 1 year | Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC |
| Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC | 1 year | Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC |
| Assessment of differences in LAS measurements at end-diastole between ECHOPAC and UWS | 1 year | Assessment of differences in LAS phase measurements between ECHOPAC and UWS |
| Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS | 1 year | Assessment of differences in LAS measurements at pre-A between ECHOPAC and UWS |
| Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS | 1 year | Assessment of differences in RAS measurements at end-diastole between ECHOPAC and UWS |
| Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS | 1 year | Assessment of differences in RAS measurements at pre-A between between ECHOPAC and UWS |
| Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients | 1 year | Inter-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients |
| Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients | 1 year | Intra-observer reproducibility assessment of manual measurements (UWS and GE) in a sample of 10 patients |
| Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients | 1 year | Inter-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients |
| Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients | 1 year | Intra-observer reproducibility assessment of AutoStrain measurements (UWS and GE) in a sample of 10 patients |
Countries
France
Contacts
CONTACTChristophe Beyls, MD
Outcome results
None listed