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Cryotherapy Versus Dexamethasone on Postoperative Pain in Permanent Mandibular Molars

Effectiveness of Cryotherapy Versus Dexamethasone on Reducing Postoperative Pain in Permanent Mandibular Molars with Irreversible Pulpitis: a Randomized Controlled Clinical Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06832254
Enrollment
60
Registered
2025-02-18
Start date
2024-04-05
Completion date
2025-01-05
Last updated
2025-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulpitis - Irreversible

Keywords

Cryotherapy, Irrevesible pulpitis, Dexamethasone, Postoperative pain

Brief summary

The goal of this clinical trial was to evaluate cryotherapy versus dexamethasone on the intensity of postoperative pain in root canal treatment procedures in mandibular first molar teeth with symptomatic irreversible pulpitis. The main question it aims to answer is: * Does controlled irrigation with cold saline in root canal treatment reduce the severity of postoperative pain? * Does controlled irrigation with dexamethasone in root canal treatment reduce the severity of postoperative pain? In the cryotherapy group, unlike the control and dexamethasone group, the root canals were irrigated with 2 °C salin solution in final irrigation. In the dexamethasone group, unlike the control and cryotherapy group, the root canals were irrigated with 1 mL dexamethasone solution in final irrigation.

Interventions

OTHERCryotherapy

The root canals were irrigated with 2 °C saline solution in final irrigation in cryotherapy group.

DRUGDexamethasone

Each root canal was irrigated with 1 mL dexamethasone solution in final irrigation in dexamethasone group.

Sponsors

Cukurova University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Vital mandibular first and second molars with 3 root canals that responded positively to the cold test and electric pulp test * Patients who had not taken analgesics or antibiotics in the last 24 hours before the procedure were included in the study.

Exclusion criteria

* Devital mandibular first and second molars that responded negatively to cold tests and electric pulp tests * Mandibular first and second molars with poor periodontal status (pocket depth \> 4 mm), * Mandibular first and second molars with 4 or more root canals detected radiographically or after opening the endodontic access cavity were excluded from the study.

Design outcomes

Primary

MeasureTime frameDescription
Visual Analogue Scaleup to 72 hoursThe visual analog scale for pain is a straight line with one end meaning no pain (0) and the other end meaning the worst pain (10) imaginable. A patient marks a point on the line that matches the amount of pain he or she feels. It may be used to help choose the right dose of pain medicine. Also called VAS.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026