Dry Eye Syndromes, Severe Dry Eye Syndromes
Conditions
Keywords
Dry Eye Syndromes, lacrimal gland, platelet-rich plasma, aqueuous deficiency
Brief summary
The investigatror wants to show the efficacy of Platelet-Rich Plasma injection in lacrimal gland to restore the lacrimal secretion in patients presenting aqueous deficiency reponsible for severe dry eye syndrome.
Detailed description
injections in lacrimal gland four times during the study for each patient
Interventions
OTHERinjections of Platelet-Rich Plasma in lacrimal gland
injections of Platelet-Rich Plasma in lacrimal gland
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
To assess the lacrimal secretion after 4 injections of PRP in lacrimal gland
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Platelet counts, and clotting factors in the standarts * Presenting with severe dry keratoconjunctivitis diagnosed by an ophthalmologist
Exclusion criteria
* Patients with significant fibrosis of the conjunctival portion of the lacrimal gland * Patients with complete stenosis of both lacrimal meatus in the treated eye
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare the lacrimal secretion after 4 monthly injections of PRP into the lacrimal gland | week 16 | Schirmer I test score between 0mm and more 20mm |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To compare the different clinical follow-up parameters of qualitative dry ocular syndrome and quantitative after 4 monthly injections of PRP into the lacrimal gland | week 16 | Ocular Surface Diseases Index (OSDI) a scale of 0 to 100 |
Countries
France
Contacts
Primary ContactDoctor Jean Philippe GROSSE, Dr
Outcome results
None listed