Aquagenic Wrinkling of Palms, Carrier State
Conditions
Brief summary
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status. Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.
Interventions
PROCEDUREAquagenic Wrinkling
Participants will be asked to remove all jewelry from the hand(s) and wrist(s) that will be undergoing the aquagenic wrinkling procedures. Photographs will be taken of the palmar surface of the hand(s). The participant will submerge the hand(s) undergoing testing in a water bath for one minute. After one minute, they will remove their hand(s), dry them gently with a towel, and photographs will be taken of the palmar surface of the hand(s). The participant will re-submerge their hand(s) in the appropriate conditions for another minute and the process will be repeated 20 times for 20 total minutes submerged in the water.
Sponsors
University of Iowa
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 24 Years
Healthy volunteers
Yes
Inclusion criteria
* Interested in participating in other CF Carrier-related research studies.
Exclusion criteria
* CF patient status * Unable to speak English * Unable to provide written informed consent * Prisoner status * An open wound on either hand * A tattoo on either hand * Missing any portion of either hand * Diagnosis of Diabetes * Diagnosis of Hyperhidrosis * Diagnosis of Raynaud's Disease * Diagnosis of Atopic Dermatitis * Regularly taking ACE inhibitors or angiotensin receptor blockers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Human Observation of Wrinkling | Up to 20 minutes | Photos of hands will be scored on a scale of 0 (no wrinkling) to 4 (severe wrinkling) at each minute by human observers. |
| Machine-Learning Observation of Wrinkling | Up to 20 minutes | Photos of hands will be scored by a machine-learning algorithm at each minute. |
Countries
United States
Contacts
CONTACTPhilip M Polgreen, MD
CONTACTShelby L Francis, PhD
PRINCIPAL_INVESTIGATORPhilip M Polgreen, MD
University of Iowa
Outcome results
None listed