IVF Outcome, Ovarian Aging, Oxidative Stress
Conditions
Keywords
oxidative stress, ovarian aging
Brief summary
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.
Interventions
DIAGNOSTIC_TESTOxidative stress markers
We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes
Sponsors
University of California, San Francisco
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 43 Years
Healthy volunteers
Yes
Inclusion criteria
1. Female age 18-43 years 2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy. 3. Male partners 18 years of age or older. 4. Must be a registered patient at UCSF Center for Reproductive Health 5. Patient and partner must both be physically present on the day of retreival
Exclusion criteria
1. Female partner age 44 or older 2. Planning fresh transfer (hybrid PGS cycle) 3. Cleavage stage biopsy 4. Planning to use frozen sperm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implantation rate | From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved) | Implantation rate of euploid embryos that result from a specific oxidative stress environment |
Countries
United States
Contacts
CONTACTElena Hoskin, BS
PRINCIPAL_INVESTIGATORMitchell Rosen, MD
University of California, San Francisco
Outcome results
None listed