Breast Cancer
Conditions
Keywords
Exercise, Breast Cancer, Endocrine Therapy, Insulin Resistance, Body Composition
Brief summary
The aim of this study is to learn more about how physical activity and cardiorespiratory fitness are related to diabetes risk among breast cancer patients prescribed an endocrine therapy.
Detailed description
80 women between the ages of 18-80 years will be recruited for this study. The study design consists of two separate in-person visits to University of Colorado Anschutz Medical Campus or Colorado State University. The study consists of glucose testing, a body composition scan, exercise testing, and a two-week period of free living activity monitoring.
Interventions
OTHERNo intervention
No intervention is performed. Participants who have been treated with either a SERM or aromatase inhibitor are recruited and analyzed in separate groups, but the study design for all participants is identical.
Sponsors
University of Colorado, Denver
Colorado State University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Female * diagnosed with breast cancer * age 18-80 years * Completed surgery, chemo- and/or radiation therapy * Prescribed aromatase inhibitor or SERM for at least one year from the time of screening
Exclusion criteria
* Age \< 18 or \> 80 * Type 1 diabetes * Type 2 diabetes * Prescribed anti-hyperglycemic medication, insulin, or sulfonylurea. * Pregnant, breastfeeding or planning to become pregnant in next 2 months * Have absolute contraindications to exercise testing which are: 1. Unstable angina 2. Recent myocardial infarction, cardiac surgery, or vascular surgery (\<3 months) 3. Uncontrolled high blood pressure 4. Heart failure 5. Peripheral artery disease (based on report of symptomatic claudication) 6. Hepatic or renal disease 7. Severe arthritis or mobility impairment that would interfere with exercise testing * Suspected cognitive impairment that would prevent understanding or comprehension of study procedures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin Resistance | Immediately after the consent form is signed | Insulin resistance will be measured through oral glucose tolerance testing |
| Body Composition | Immediately after the insulin resistance measurement | Body composition will be measured through DEXA scan |
| Maximal Exercise Capacity | Within 2-60 days of insulin resistance measurement | Maximal exercise capacity measured through graded exercise test on stationary bicycle |
| Daily Activity | 2-60 days following insulin resistance measurement | Daily activity measured using activity monitor |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORRebecca Scalzo, PhD
University of Colorado, Denver
Outcome results
None listed