Laryngeal Dystonia
Conditions
Brief summary
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
Detailed description
Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.
Interventions
DEVICEStarstim system
Transcranial direct current stimulation (tDCS)
Sponsors
Yale University
National Spasmodic Dysphonia Association
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
Subjects and staff will be blind during the study and that subjects will be told of their assignment at the follow-up visit.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants) * No other known or history of speech, voice disorder other than LD. * Provision of signed and dated informed consent form. * Stated willingness to comply with all study procedures and availability for the duration of the study * Must not be pregnant.
Exclusion criteria
* All individuals who do not meet the above mentioned criteria are excluded from the study. * Subjects with a history of epilepsy or depression or is claustrophobic.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Cepstral peak prominence (CPP) | daily on Day 1-Day 5 | Cepstral peak prominence (CPP) as a robust objective measure of voice quality in the active, sham and no stimulation conditions. |
| Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) | daily on Day 1-Day 5 | Its primary purpose is to describe the severity of auditory-perceptual attributes of a voice problem, in a way that can be communicated among clinicians |
Countries
United States
Contacts
CONTACTNabin Koirala, PhD
PRINCIPAL_INVESTIGATORNabin Koirala, PhD
Yale University
Outcome results
None listed