Gut -Microbiota, Inflammation Biomarkers, Joint Pain, Pain Assessment
Conditions
Brief summary
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.
Interventions
DIETARY_SUPPLEMENTWild blueberry
Freeze-dried wild blueberry powder 25g/day
DIETARY_SUPPLEMENTPlacebo
Placebo powder matched for calories and no polyphenols
Sponsors
Oklahoma Medical Research Foundation
University of Nevada, Las Vegas
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Adults with documented multi-joint/knee arthritis
Exclusion criteria
* inability to give informed consent * pregnancy or lactation * planned knee replacement surgery * allergy or contraindication to berries * recent trauma of the knee responsible of the symptomatic knee * intra-articular injection in the target knee/hip in the last 3 months * oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline * use of berry extracts in the last 3 months * special diets * cancer treatment * bone diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum biomarkers of joint function | 12 weeks | Serum biomarkers of inflammation and cartilage degradation will be measured in the wild blueberry and placebo groups and compared for outcomes. Pain scores will also be measured using self-reported questionnaires. |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiome | 12 weeks |
Countries
United States
Contacts
Primary ContactArpita Basu
Outcome results
None listed