Premature Newborns, Premature Newborns With Gestational Age 28 to 33 Weeks
Conditions
Keywords
Apnea of prematurity, Interleukin-1β, Prostaglandin E2, Outcome
Brief summary
Our thesis proposed that IL-1β may affect brainstem respiratory control via prostaglandin-dependant mechanism so we investigated the mediator roles of IL-1β and PGE2 levels in predicting apnea in pretertm newborn and their relation to clinical outcomes.
Interventions
DIAGNOSTIC_TESTBlood test
Blood samples were withdrawn from all the neonates under strict aseptic conditions and stored at -80°C for detecting PGE2 and IL-1β levels. PGE2 and IL-1β concentrations were measured using ELISA.
Sponsors
Benha University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 2 Months
Healthy volunteers
No
Inclusion criteria
* Preterm infants born at less than 37 weeks of gestation. * Neonates aged from birth up to 28 days. * Neonates diagnosed with apnea of prematurity or exhibiting apneic episodes
Exclusion criteria
* Full-term neonates. * Neonates with major congenital malformations or genetic syndromes. * Neonates with severe neurological impairments (e.g., intraventricular hemorrhage grade III or IV). * Neonates with confirmed or suspected sepsis or active infections. * Neonates receiving steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other medications known to alter interleukin-1β or prostaglandin E2 levels. * Neonates with congenital heart diseases. * Neonates with a history of significant birth asphyxia requiring extensive resuscitation. * Neonates whose parents or guardians refuse to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of NICU stay | 1 month |
| Mortality rate | 1 month |
Countries
Egypt
Outcome results
None listed