Acute Respiratory Distress Syndrome, Electrical Impedance Tomography, Prone Position
Conditions
Brief summary
The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position.
Detailed description
The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position. Therefore, the investigators propose a project with the aim of collecting relevant clinical, laboratory, imaging, and respiratory physiology data from consenting patients with ARDS within the study period. The objective is to analyze changes in biomarkers following prone position.
Interventions
DEVICEElectrical Impedance Tomography
It utilizes electrical impedance tomography to analyze a series of physiological changes in the lungs following treatment
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Acute respiratory distress syndrome 2. Age \> 18 3. Serial arterial blood gas data：PaO2/FiO2 \<150. The mechanical ventilator setting：FiO2\>0.6, PEEP\>5 cmH2O
Exclusion criteria
1. Implantable electronic devices (e.g., pacemakers) 2. Body mass index \> 30 3. Major thoracic and abdominal surgery 4. Patients with unstable spine and pelvis conditions 5. Pregnant women in the second and third trimesters 6. Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure 7. Hemodynamically unstable patients unsuitable for prone ventilation therapy 8. Patients with active seizures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prone response | During the prone position(5 days) | Responder is defined as an increase in PaO2 by 20 mmHg or an increase in PaO2/FiO2 by 20% one hour after receiving prone position therapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | On the 28th day | The mortality status on the 28th day |
Countries
Taiwan
Contacts
Primary ContactTing-Yu Liao, MD
Outcome results
None listed