Mechanical Ventilation Complication, Respiratory Acidosis
Conditions
Brief summary
This is a randomized, open-label study comparing intial settings made by clinicians with settings recommandation made by the VentilO application immediately after intensive care unit admission.The study will allow direct comparison of the frequency of acidosis when patients are ventilated using the parameters of the VentilO application versus parameters chosen by the clinician. The variables determined by the clinician or VentilO will be respiratory rate, tidal volume and resulting minute ventilation.
Interventions
OTHERClinicians
Clinicians will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit.
DEVICEVenitlO
VentilO application (or web platerform) will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit.
Sponsors
Laval University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (\> 18 years old) * Intubated patients admitted to intensive care immediately post-operatively after cardiac surgery (all cardiac surgery combined) * Ventilation in controlled mode (Assist Control or SIMV)
Exclusion criteria
* Absence of anthropometric data (height and weight) of patients available in the patient file * Respiratory cycles mainly spontaneous on arrival * Patient extubated on arrival in intensive care
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory acidosis | 20 minutes after initiation of mechanical ventilation | The frequency of respiratory acidosis on arterial gas after 20 minutes of mechanical ventilation (pH \< 7.35 and PaCO2 \> 45mmHg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Acid-base disorders on arrival in intensive care | 5 minutes after initiation of mechanical ventilation | The frequency and severity of acid-base disorders on arrival in intensive care (pH\<7.35 or pH \> 7.45) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Mortality | Up to intensive care unit discharge | Intensive care unit mortality |
| Intensive care unit lenght of stay | Up to 28 days - intensive care unit length of stay - intensive care admission to intensive care discharge | Intensive care unit lenght of stay |
| Number of participants with an acute kidney injury | Up to 28 days - intensive care unit length of stay - intensive care admission to intensive care discharge | Acute kidney injury define by \> 27 mmol for 48 hours or 1.5 x basline value (pre surgery) |
| Number of participants with a barotrauma | Up to extubation | Presence of pneumothorax |
| Number of participants with hemodynamic shock - hypotension | Up to extubation | Requiring \>1L of volume repletion and/or use of amines at \>0.05 mcg/kg/min or norepinephrine equivalent |
Countries
Canada
Contacts
Primary ContactFrancois Lellouche Principal investigator, MD, PhD
Outcome results
None listed