Obesity and Overweight
Conditions
Keywords
microplastics, obesity, macro-genomic, metabolomics
Brief summary
The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the association between obesity and visceral microplastics, and to investigate the effects of microplastics on the visceral microbiota and metabolic profiles of obese patients by combining the macro-genomic and metabolomics approaches.
Interventions
DIAGNOSTIC_TESTMeasuring the microplastics
Measuring the type, nature, and abundance of microplastics in stomach, liver, feces, and blood
Sponsors
First Affiliated Hospital of Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years old; * BMI ≧30; * proposed to undergo bariatric surgery and need to remove part of the liver tissue for fatty liver test; * complete clinical data and basic information; * willing to participate in the study and sign the informed consent form.
Exclusion criteria
* Receive chemotherapy, radiotherapy, immunotherapy; * have other history of digestive diseases; * combined with malignant tumors; * have serious cardiorespiratory insufficiency and other systemic diseases that affect the choice of treatment plan; * not willing to participate in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences in microbial communities | From the diagnosis of obesity, through study completion, an average of 1 year. | Differences in different microbial communities in the stomach, liver, feces, and blood of obese patients |
Countries
China
Outcome results
None listed