Hypertension, Ethnicity and Exercise Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06824805

Acronym

HYPE2X

Enrollment

Registered

2025-02-13

Start date

2020-06-01

Completion date

2023-11-30

Last updated

2025-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Brief summary

The main aim of this study is to investigate the acute effects of a single bout of isometric handgrip exercise (IHG) and a single bout of aerobic endurance exercise (AEX) on blood pressure, both immediately after exercise and during the subsequent activities of daily living in patients with high-normal to grade 1 hypertension of South-Asian or African descent living in Suriname.

Interventions

BEHAVIORALExercise

aerobic exercise for 30 minutes at 40-60% HRres

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* • Age 18 - 65 years * Patients with high- normal BP (SBP: 130 - 139 mmHg or and DBP: 85 - 89 mmHg) or stage I hypertension (SBP: 140 - 159 mmHg or DBP: 90 - 99 mmHg) according to the ESC/ESH guidelines \[15\] * Asian or African descent * Do not meet the level of physical activity recommended by the WHO based on self-report \[15\] * Non-medicated patients or patients using a maximum of 2 antihypertensive drugs

Exclusion criteria

* • Functional or mental limitation limiting the correct execution of an exercise bout * History of ischemic stroke, autonomic neuropathy, cardiovascular, renal, or pulmonary disease by self-report * Diabetes type I or II * Pregnancy * The presence of exercise induced signs of myocardial ischemia or complex ventricular arrhythmia during CPET * Patients using three or more antihypertensive drugs or patients with resistant hypertension

Design outcomes

Primary

Measure	Time frame	Description
office blood pressure at 30 minutes post exercise	30 minutes postexercsie	office blood pressure at 30 minutes post exercise

Secondary

Measure	Time frame	Description
daytime blood pressure	mean of 8 hours after the intervention	daytime ambulatory blood pressure (8 hours after the intervention)

Countries

Suriname

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026