Stroke, Ischemic, Stroke Patients
Conditions
Keywords
stroke, cognitive functions, neurotrophins, neurological rehabilitation
Brief summary
The aim of this randomised experimental study is to test the effect of different intensities of aerobic exercise on neurotrophin concentration and functional and cognitive functions in post-stroke patients undertaking a single bout and 3-week exercise programme. The main questions to answer are: 1. What is effect of different intensities of aerobic exercise on functional abilities in post-stroke patients undertaking a 3-week aerobic exercise programme? 2. What is effect of different intensities of aerobic exercise on cognitive functions in post-stroke patients undertaking a 3-week aerobic exercise programme? 3. What is effect of different intensities of aerobic exercise on neurotrophin concentration in post-stroke patients undertaking a 3-week aerobic exercise programme? 4. What is effect of different intensities of 45-min single bout aerobic exercise on neurotrophin concentration in post-stroke patients? The participants were randomly assigned to one of two groups: moderate-intensity continuous training on a bicycle ergometer and standard neurorehabilitation or low-intensity continuous training on a bicycle ergometer and standard neurorehabilitation. Training on a bicycle ergometer was performed four times a week for 45 min for 3 weeks. Each participant attended individual neurorehabilitation sessions 11 times per week (2 physical therapy sessions from Monday to Friday for 45 min each and 1 session on Saturday for 45 min) during the 3-week intervention. Participants will have pre-tests and post-tests: * blood samples collection (to measure level of brain-derived neurotrophic factor, glial cell derived neurotrophic factor, insulin-like growth factor, vascular-endothelial growth factor, irisin), * body mass index * The Graded Cycling Test with Talk Test * 6-Minute Walk Test * Rivermead Motor Assessment * Barthel Index * Addenbrooke's Cognitive Examination * Vo2max * Beck Depression Inventory Researchers will compare two groups - moderate intensity continuous group and low intensity continuous group to see if there is a modulating effect of different intensities of exercise in participants' outcomes.
Interventions
BEHAVIORALExercise
Training on a bicycle ergometer was performed four times a week for 3 weeks for 45 min. The exercise intensity corresponded to 50%-60% of maximal oxygen uptake (VO2max).
Sponsors
Poznan University of Physical Education
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age 21-75 years, * first episode of ischemic stroke confirmed by magnetic resonance imaging (MRI) or computed tomography (CT), * able to walk for 4 m at a self-selected speed independently or with an assistive device (as needed), * be in a stable clinical condition, * able to communicate with investigators, * provided written informed consent to participate in the study.
Exclusion criteria
* aphasia, * an unstable cardiac status (e.g., evidence of significant arrhythmia or myocardial ischaemia), * lower extremity claudication, * weight-bearing pain \>4/10, * lower extremity spasticity (i.e., an Ashworth Scale score \>2), other neurological conditions in addition to stroke, * chronic degenerative or inflammatory diagnoses, malignancies, and visuospatial neglect.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain-derived neurotrophic factor | Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention | Level of brain-derived neurotrophic factor in ng/ml |
| Glial cell derived neurotrophic factor | Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention | Level of glial cell derived neurotrophic factor in ng/ml |
| Insulin-like growth factor | Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention | Level of insulin-like growth factor in ng/ml |
| irisin | Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention | Level of irisin in ng/ml |
| Vascular-endothelial growth factor A | Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention | Level of Vascular-endothelial growth factor A in ng/ml |
| The Graded Cycling Test with Talk Test | Before and after 3-week intervention | Cardiorespiratory fitness assessment with the Graded Cycling Test with Talk Test assess submaximal exercise in Watt. Higher Watt means better outcome. |
| Vo2max | Before and after 3-week intervention | Physical performance assessment with Vo2max in mL/min/kg. |
| Six Minute Walk Test | Before and after 3-week intervention | The 6 minute walking test assesses functional capacity during continuous walking on a 12-m ward hallway for 6 min. The test measures the distance a patient walks in 6 min. |
| Rivermead Motor Assessment | Before and after 3-week intervention | Functional mobility among post-stroke patients was assessed with the Rivermead Motor Assessment, a performance-based measure in points. This later includes 38 items that cover three sections: gross function, leg and trunk and arm function. The total score ranges from 0 to 38 points. Higher scores indicate a higher degree of functional mobility. |
| Barthel Index | Before and after 3-week intervention | The Barthel Index is a scale that measures an individual's functional outcomes. It consists of 10 items that assess activities of daily living, functional mobility, and gait. The score ranges from 0 to 100 points. The higher the score, the greater the individual's ability to self-care |
| Addenbrooke's Cognitive Examination | Before and after 3-week intervention | Cognitive functions assessment with Addenbrooke's Cognitive Examination in points. Higher scores means better outcome. |
| Beck Depression Inventory | Before and after 3-week intervention | Depressive symptoms assessment with Beck Depression Inventory in points. Higher scores means worse outcome. |
Countries
Poland
Outcome results
None listed