Diabetes, Diabetic Retinopathy, Type 2 Diabetes Mellitus (T2DM)
Conditions
Brief summary
This study aims to integrate clinical indicators and features of fundus images, combined with metabolomics, to construct an early warning model for diabetic retinopathy (DR) in type 2 diabetes. By combining clinical indicators with metabolomics, the investigators aim to establish a precise DR typing model based on the age of diabetes onset (early-onset diabetes, late-onset diabetes) and based on the coexistence with two types of diabetic macrovascular complications. A multidisciplinary collaboration will be conducted for comprehensive management of DR to control the progression of moderate-stage DR. Cloud-based patient rooms combined with continuous glucose monitoring (CGM) will further explore the role of integrated diabetes retinopathy ward management models in the management of patients undergoing diabetes retinopathy surgery, pioneering a new model for the management of advanced DR.
Interventions
DIAGNOSTIC_TESTFundus Examination
Performing fundus photography on patients to assess the progression of diabetic retinopathy (DR).
DIAGNOSTIC_TESTMetabolomics analysis
Conduct metabolomics testing at enrollment.
Sponsors
Yufan Wang
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Meets the diagnostic criteria for type 2 diabetes in the China Type 2 Diabetes Prevention and Treatment Guidelines (2020 Edition); * Aged between 20 and 79 years old, without other severe underlying diseases; ③ Possesses full cognitive and literacy abilities; ④ Volunteers to participate in this study and are willing to sign an informed consent form.
Exclusion criteria
* Those who have been diagnosed with type 1 or other types of diabetes; * Those with severe cardiac, pulmonary, hepatic, or renal insufficiency; * Those with mental confusion, speech disorders, or dementia, etc.; * Those who are unable to take care of themselves, bedridden, or have mobility impairments; ⑤ Women who are breastfeeding or pregnant; * Those with a recent history of surgery, trauma, acute major vascular complications, or infectious diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fundus examination | Conduct examinations at enrollment and twelve months after enrollment. | Assess the severity of diabetic retinopathy (DR), and group accordingly. The high - risk DR cohort and the early - stage DR cohort have a fundus examination once a year; the mid - stage DR cohort has a fundus examination every six months; the late - stage DR cohort has a fundus examination every three months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metabolomics analysis | at enrollment | By metabolomics, we aim to establish a precise DR typing model based on the age of diabetes onset (early-onset diabetes, late-onset diabetes) and based on the coexistence with two types of diabetic macrovascular complications so that we can better prevent and treat diabetic retinopathy. |
| Triglycerides | Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment. | — |
| Glycated Hemoglobin | Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment. | — |
| Insulin levels | Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment. | — |
| Total Cholesterol | Conduct examinations at enrollment, six months after enrollment, and twelve months after enrollment. | — |
Countries
China
Contacts
Primary ContactLiping Gu Liping Gu
Outcome results
None listed