Hyperinflammation and Hyperferritinemia in Critically Ill Patients

Hyperinflammation and Hyperferritinemia in Critically Ill Patients: a Retrospective Observational Single-center Analysis

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06820905

Acronym

HYFER

Enrollment

1962

Registered

2025-02-11

Start date

2025-02-20

Completion date

2025-11-30

Last updated

2025-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Illness, Hyperferritinemia, Hyperinflammatory Syndrome, Sepsis

Keywords

criticall illness, sepsis, ferritin, hyperinflammatory syndrome, sepsis phenotype

Brief summary

Analysing trajectory of critically ill patients with signs of hyperinflammation

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* critically ill patients * admission between 01.01.2020 and 31.12.2024 (5yrs)

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame	Description
hyperferritinemia	2025	trajectory of critically ill patients with significant hyperferritinemia and with regard to its dynamics; ferritin value cutt-off

Secondary

Measure	Time frame	Description
etiology and association of hyperferritinemia	2025	etiology and association of hyperferritinemia with infectioius a non-infectious diseases/conditions
mortality a morbidity	2025	mortality a morbidity of patients with significant hyperferritinemia
treatment strategy	2025	association of hyperferritinemia and treatment strategy
stratification	2025	patient stratification according to hyperferritinemia/hyperinflammation

Countries

Czechia

Contacts

Primary ContactThomas Karvunidis, MD, PhD

karvunidist@fnplzen.cz+420776160620

Outcome results