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Preventive Effect of H.Pylori Eradication on Osteoporosis

Preventive Effect of Helicobacter Pylori Eradication on Osteoporosis in Females: Prospective Observational Cohort Study for Up to 20 Years

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06818591
Enrollment
846
Registered
2025-02-10
Start date
2003-05-31
Completion date
2023-06-30
Last updated
2025-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HELICOBACTER PYLORI INFECTIONS, Osteoporosis

Keywords

Helicobacter pylori eradication, osteoporosis, Sex difference, Age

Brief summary

In this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received Helicobacter pylori eradication and examined differences by age and sex.

Detailed description

In this study, the investigators observed the long-term incidence rate of osteoporosis in patients who received Helicobacter pylori eradication and examined differences by age and sex. In addition, the investigators will analyze the correlation between the incidence of osteoporosis by comparing confounding factors such as body mass index, steroid use, and proton pump inhibitor use as well as the eradication status of H. pylori.

Interventions

DIAGNOSTIC_TESTDEXA(Dual-Energy X-ray Absorptiometry)

Followed for up to 20 years

Sponsors

Seoul National University Bundang Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No

Inclusion criteria

ㆍPatients tested Helicobacter pylori status

Exclusion criteria

ㆍPatients aged \< 20 years ㆍPatients with unknown Helicobacter pylori bone density status ㆍPatients with with a history of gastric cancer ㆍPatients with prior Helicobacter pylori eradication therapy ㆍPatients with a history of osteoporosis

Design outcomes

Primary

MeasureTime frame
the incidence of new-onset osteoporosisThe patients were prospectively monitored until they either developed osteoporosis or reached the study endpoint in February 2023, whichever occurred first.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026