Primary Teeth, Pulpitis - Irreversible, Pulp Necrosis
Conditions
Keywords
lesion sterilization and tissue repair, antibiotics
Brief summary
This study aimed to assess the clinical and radiographic success of lesion sterilization and tissue repair (LSTR) therapy with different antibiotic combinations, focusing on evaluating whether the alternative combination of clindamycin instead of minocycline is as effective as the standard 3Mix-MP formulation.
Detailed description
All the clinical procedures were carried out by one clinician with 2 years of clinical experience in pediatric dentistry under rubber dam isolation and local anesthesia via mandibular nerve block. (Maxicaine Fort Ampoule, VEM, Turkiye). After the removal of carious tissues, an endodontic cavity was prepared, and infected coronal pulp tissue was removed up to the canal orifices via a sterile round steel bur. A sterile round steel bur was then used to prepare a medication cavity 2 mm deep and 1 mm wide. The root canals were not instrumented, and only the access cavity was irrigated with a 2.5% NaOCl solution. In cases where hemostasis could not be achieved, a sterile cotton pellet soaked in 5% NaOCl was placed in the pulp chamber and left for 1 minute. Once hemostasis was achieved, the endodontic cavity was dried using a sterile, dry cotton pellet. Pastes were then applied to the medication cavity and covered with a glass ionomer cement (Nova Glass II F, Imicryl, Turkiye) and a stainless steel crown (Kids Crown, Shinhung, Seoul, Korea) at the same visit. Clinical and radiographic evaluations were performed at 1, 3, 6, 9, and 12 months. During follow-up, the teeth were assessed on the basis of the following clinical criteria: pain, dentoalveolar abscess and/or fistula, and tooth loss. The radiographic criterion was periapical radiolucency.
Interventions
PROCEDURELesion Sterilization and Tissue Repair Therapy
LSTR treatment is a minimally invasive, cost-effective, and easy-to-apply procedure for necrotic primary teeth, with a focus on disinfection with an antibiotic mixture without the need for root canal instrumentation.
DRUGDifferent Antibiotic Combinations
Clinical and Radiographic Success of Different Antibiotic Combinations (evaluating whether the alternative 3Mix-MP combination of clindamycin instead of minocycline is as effective as the standard 3Mix-MP formulation) in Lesion Sterilization and Tissue Repair Therapy
Sponsors
Inonu University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
This study was a randomized controlled clinical trial that followed the recommendations of the Consolidated Standards of Reporting Trials (CONSORT).
Eligibility
Sex/Gender
ALL
Age
3 Years to 10 Years
Healthy volunteers
Yes
Inclusion criteria
* Spontaneous pain * Pain on percussion * The presence of abnormal or pathological mobility * The presence of a sinus tract or dentoalveolar abscess * Widening of the periodontal ligament * Periradicular radiolucency * Evidence of external and/or internal resorption.
Exclusion criteria
* Who required infective endocarditis prophylaxis * Who had used antibiotics in the two weeks prior to treatment * İndividuals allergic to the medications used in the study * Teeth with pulp floor perforation * Advanced internal and/or external root resorption * Root canal obliteration * Excessive bone loss in the furcation area involving the permanent tooth follicle * Teeth with severe coronal destruction, nonrestorable.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical success | 12 months | clinical criteria: pain, dentoalveolar abscess and/or fistula, and tooth loss. |
| radiographic success | 12 months | radiographic criterion was periapical radiolucency. |
| overall success | 12 months | If at least one of the clinical findings was present, the treatment was considered unsuccessful. However, even if teeth fail radiographically, they are not classified as overall failure if no clinical signs are present. |
Countries
Turkey (Türkiye)
Outcome results
None listed