Retrospective Evaluation of the Impact of Epidural on the Risk of Postpartum Hemorrhage

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06816654

Enrollment

5753

Registered

2025-02-10

Start date

2023-12-12

Completion date

2024-05-22

Last updated

2025-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum Hemorrhage

Keywords

Epidural anesthesia, Postpartum hemorrhage, Obstetric analgesia, Neuraxial anesthesia, Instrumental delivery, Obstetrical trauma

Brief summary

Postpartum hemorrhage (PPH) is a major complication of childbirth. Epidurals are often implicated in the onset of postpartum hemorrhages. Given the paradoxical data in the literature, the investigators wished to retrospectively evaluate the impact of epidurals on the risk of PPH, instrumental delivery and the occurrence of PPH risk factors. The investigators retrospectively analyzed 5753 records of patients who gave birth vaginally at Brugmann University Hospital between January 1, 2020 and December 31, 2021. The primary objective was to assess whether epidurals pose a risk of postpartum hemorrhage. Secondly, the investigators assessed whether epidurals pose a greater risk of instrumentation of delivery and emergence of PPH risk factors.

Interventions

OTHERData extraction from medical records

Data extraction from medical records

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who gave birth vaginally at the Brugmann University Hospital Horta site between January 1, 2020 and December 31, 2021.

Exclusion criteria

* Patients who gave birth before 25 weeks. * Patients who gave birth outside of hospital. * Patients who had recourse to a medical termination of pregnancy (MTP). * Patients who gave birth by cesarean section.

Design outcomes

Primary

Measure	Time frame	Description
Postpartum blood loss	Up to 24 hours after the birth of the baby	Total blood loss is analyzed according to a standardized protocol: use of the calibrated field of the collection bag and of a precision scale to weigh the blood soaked compresses

Secondary

Measure	Time frame	Description
PPH risk factors	Data extraction in medical files from January 1st 2020 till December 31th 2021	Presence/absence of one or more PPH risk factors (yes/no) such as : uterine atony, placental abnormalities, obstetric trauma, and coagulopathy.

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026