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Pneumatic Compression vs Blood Flow Restriction for Muscle Recovery

Comparing the Effects of Pneumatic Compression and Blood Flow Restriction Therapy on Muscle Recovery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06815367
Enrollment
33
Registered
2025-02-07
Start date
2024-01-15
Completion date
2026-05-01
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delayed Onset Muscle Soreness

Brief summary

Both BFR and intermittent pneumatic compression are purported to decrease symptoms associated with exercise induced muscle damage (EIMD) that cause delayed onset muscle soreness (DOMS). Blood flow restriction relies on applying pressurized cuffs to the most proximal portion of the limb. Another form of recovery often relied upon is pneumatic compression. The mechanism by which pneumatic compression works is similar to that of a massage, whereby the device progressively increases the pressure on a portion of the limb before releasing and moving further up the limb.The purpose of this study is determine whether BFR or pneumatic compression can be used to decreased DOMS which may indicate enhanced recovery.

Interventions

Following downhill running protocol, participants will complete 20 minutes of pneumatic compression at 100 mmHg.

DEVICEBlood Flow Restriction

Following the downhill running protocol, participants will complete 4 rounds of treatment: 3 minutes at 100% resting limb occlusion pressure, 2 minutes of 0% resting limb occlusion pressure.

Sponsors

University of Southern California
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* 18-30 years of age * Recreationally active population * Women should be on a form of hormonal contraception. * No current musculoskeletal injuries or pathologies * Must answer "yes" to all PAR-Q questions.

Exclusion criteria

* Individuals that routinely train trail running * Discomfort when running * Deep vein thrombosis * Blood clots * Cancerous lesions * Sensory or mental impairment * Unstable fractures * Acute pulmonary edema * Acute thrombophlebitis * Acute congestive cardiac failure * Acute infections * Episodes of pulmonary embolism * Wounds, lesions, infection, or tumors * Bone fractures or dislocations * Increased venous and lymphatic return * Answers "no" to any of the PAR-Q screening questions

Design outcomes

Primary

MeasureTime frameDescription
Counter Movement Jump HeightImmediately before and immediately after exercise, immediately after treatment, 24-hours post treatment.Participants will be asked to complete three consecutive counter movement jumps with hands on hips. The CMJ will be used as an indirect measure of muscle function.
Maximal Voluntary Isometric ContractionImmediately before and immediately after exercise, immediately after treatment, 24-hours post treatment.Participants will be asked to complete an MVIC to assess muscle function.
Sedentary delayed onset muscle sorenessImmediately before and immediately after exercise, immediately after treatment, 24-hours post treatment.Using a visual analog scale, participants will be asked to rate their level of soreness while at rest.
Active delayed onset muscle sorenessUsing a visual analog scale, participants will be asked to rate their level of soreness while at rest.Using a visual analog scale, participants will be asked to rate their level of soreness while completing a wall sit.

Countries

United States

Contacts

CONTACTBailey McLagan, MS
mclagan@usc.edu323-442-2498

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 31, 2026