Cardiometabolic Conditions, Osteopenia
Conditions
Keywords
biomarkers, bone metabolism, exercise, whole-body electromyostimulation, female dentists
Brief summary
Due to their high workload and unfavorable working position, young female dentists are particularly at risk of cardiometabolic diseases and an early reduction in bone mineral density (BMD). With focus on the latter issue, short bouts of resistance exercise with high strain magnitude and velocity are commonly considered to be a feasible option to prevent bone loss in the early years of young adulthood. In parallel, whole-body electromyostimulation (WB-EMS) a trainings technology able address all main muscle groups simultaneously, however with dedicated exercise intensity might be a time-effective, joint friendly and safe option to maintain BMD in people unable or unmotivated to exercise conventionally. In the present study, we aim to compare the effects of a single session of WB-EMS versus high intensity, high velocity resistance exercise on biomarkers of bone formation (Procollagen type 1 N propeptide, P1NP) and resorption (C-terminal telopeptide of type I collagen, CTX-I). We hypothesize that no clinically relevant different effects on P1NP and CTX-I were determined.
Interventions
20 min of WB-EMS (bipolar, 85 Hz, 350 µs, 6s impulse - 4s impulse break)
OTHERResistance exercise
High-intensity/high velocity multiple set resistance exercise
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcome assessor were not aware of the group status and were not allowed to ask correspondingly
Intervention model description
Randomized two-arm cross-over design
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
* female dental students (\>3rd semester) or licensed dentists * no competitive sports background for \>2 years * normal body mass (BMI\>18,5 and \<25 kg/m2)
Exclusion criteria
* more than one resistance exercise session per week (last 12 month) * whole-body electromyostimulation during the last 12 month * amenorrhea, oligomenorrhea
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes for C-terminal telopeptide of type I collagen from pre- to 15 min post-exercise | Immediately pre-exercise to 15 min post exercise of a single exercise session | Changes for C-terminal telopeptide of type I collagen (CTX-I) serum levels from pre- to 15 min post-exercise as determined by blood samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes for Procollagen type 1 N propeptide from pre- to 15 min post-exercise | Immediately pre-exercise to 15 min post exercise of a single exercise session | Changes for Procollagen type 1 N propeptide (P1NP) serum levels from pre- to 15 min post-exercise as determined by blood samples |
| Changes for resting glucose from pre- to 15 min post-exercise | Immediately pr to 15 min post-exercise of a single exercise session | Changes for resting glucose serum levels from pre- to 15 min post-exercise as determined by blood samples |
| Changes for hemoglobin A1c from pre- to 15 min post-exercise | Immediately pre- to 15 min post-exercise of a single exercise session | Changes for hemoglobin A1c (HBA1C) serum levels from pre- to 15 min post-exercise as determined by blood samples |
Countries
Germany
Contacts
PRINCIPAL_INVESTIGATORWolfgang Kemmler, PhD
University Hospital Erlangen, Germany
Outcome results
None listed