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Evaluation of Placental Transfusion Techniques in Prevention of Prematurity Related Complications and Effect on Their Hematological Profile

Evaluation of Placental Transfusion Techniques in of Prematurity Related Complications and Hematological Profile

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06812507
Enrollment
160
Registered
2025-02-06
Start date
2025-03-10
Completion date
2026-04-28
Last updated
2026-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Placental Transfusion, Premature

Brief summary

The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in premature neonates over the first days of life

Interventions

PROCEDUREintact umbilical milking

Umbilical cord milking will be performed by holding the newborn at or ∼20 cm below the level of the placenta. The cord will be pinched between 2 fingers as close to the placenta as possible and milked toward the infant over a 2-second duration. The cord will then be released and allowed to refill with blood for a brief 1- to 2-second pause between each milking motion. This will be repeated for 2-4 times. After completion, the cord will be clamped, and the neonate will be handed to the resuscitation team.

PROCEDUREcut umbilical milking

Another technique, used more often in Asia, involves clamping and cutting a long segment of the umbilical cord immediately at birth and passing the baby and the long cord to the pediatric provider, called C-UCM untwists the cord and milks the entire contents into the baby. Milking the cord 2-3 times before clamping may produce a similar placental transfusion as C-UCM

PROCEDUREDelayed cord clamping

Infants placed on the maternal abdomen or at the introitus below the level of placenta and waiting at least 30- to 60-second before clamping the cord.

Sponsors

Alexandria University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
1 Years to 2 Years
Healthy volunteers
Yes

Inclusion criteria

* Inclusion Criteria: 1. Premature neonates ≤ 32 weeks gestational age regardless birth weight 2. patients should be admitted to neonatal intensive care unit in the first day of life of life

Exclusion criteria

*

Design outcomes

Primary

MeasureTime frameDescription
Hemoglobin levelon admission (In first day after birth),as well as, at end of first , second and third weeks of liveshemoglobin level will be measured in gram/dl

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026