Disease, Growth & Development, Human Microbiome, Pediatrics
Conditions
Brief summary
Prediction and treatment of pediatric diseases and long-term outcomes through microbiome and multi-omics analysis by life cycle: We aim to demonstrate that a wide range of diseases are associated with gut microbiome dysbiosis and to investigate the subsequent recovery (restoration) or further deterioration of the gut microbiome over time. This study seeks to offer a novel perspective on changes in the gut microbiome, particularly in the context of the gut-lung and gut-brain axes.
Detailed description
Fecal samples are collected and analyzed from birth through childhood, including those from both preterm and term infants. Based on these collected samples, groups are categorized into disease groups commonly observed in children. Genomic DNA is extracted from the fecal samples, followed by high-throughput 16S rRNA amplicon sequencing to analyze the microbial composition. Additionally, multiomics analyses, including metabolomics, are conducted to provide a comprehensive understanding of gut microbiome dynamics. The impact on the microbiome is further investigated in vitro using a fermenter-based intestinal microbiota model system.
Interventions
None listed
Sponsors
Hanyang University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* children (including newborns) who have obtained their consent from their guardians
Exclusion criteria
* subjects who did not obtain consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Follow-up of growth percentile in height, weight, and head circumference | 2 months old, 4 months old, 6 months old, 1 year old, and then every year until the age of ten years | Monitoring the baby's growth status compared to the Nomogram growth chart |
| Obervation of age-specific developmental milestones | 4 months old, 1 year old, 3 years old, school age | Judging whether the development status is appropriate according to developmental milestones based on developmental screening tests and doctors' opinions) |
| Observations on the incidence and frequency of enteritis, sepsis, and respiratory diseases | 2 months old, 4 months old, 6 months old, 1 year old, and then every year until the age of ten years | The dysbiosis of the gut microbiome affects various organs, such as the gut-lung axis and the gut-brain axis, in addition to the disease of the intestine itself, so monitor the occurrence of infectious diseases |
Countries
South Korea
Contacts
Primary ContactHyun-Kyung Park, MD
Outcome results
None listed