Post-stroke Epilepsy, Post-stroke Seizure, Thrombolytic (t-PA) Treatment
Conditions
Brief summary
This retrospective cohort study was conducted by reviewing the records of consecutive patients referred to Bu Ali Sina Hospital from 2016 to 2023, who were hospitalized with a diagnosis of ischemic stroke. The records of all patients treated with intravenous alteplase during the above period were extracted, and the relevant characteristics were recorded in a questionnaire. In each year, patients with ischemic stroke who were not treated with alteplase but were hospitalized at the Bu Ali Center were selected in a similar number to patients who received alteplase in the same year, and the relevant information was extracted from their records and recorded in a questionnaire. The incidence of post-stroke seizures and epilepsy was determined in both groups, and the factors associated with their incidence were studied and compared.
Interventions
None listed
Sponsors
Mazandaran University of Medical Sciences
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of ischemic stroke * Treatment with IV alteplase
Exclusion criteria
* History of epilepsy * Taking antiseizure medications * Unavailable patients * Unreliability of recorded patients' files
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence rate of post-stroke seizure | within 7 days following ischemic stroke onset | Incidence rate of post-stroke seizure in patients who received alteplase compared to patients who did not receive alteplase. |
| Incidence rate of post-stroke epilepsy | 1 to 7 years following ischemic stroke onset | Incidence rate of post-stroke epilepsy in patients who received alteplase compared to patients who did not receive alteplase. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Factors related to post-stroke seizure occurrence | within 7 days following ischemic stroke onset | Demographic factors are registered in the questionnaire based on the patients' files. The severity of ischemic stroke is determined by the National Institutes of Health Stroke Scale (NIHSS). Brain CT findings including territory of infarct, cortical involvement and hemorrhagic transformation are investigated by reviewing the CT scans and recording the results in the questionnaire. Correlation of each mentioned factor with post-stroke seizure occurrence will be assessed using statistical methods. |
| Factors related to post-stroke epilepsy occurrence | 1 to 7 years following ischemic stroke onset | Demographic factors are registered in the questionnaire based on the patients' files. The severity of ischemic stroke is determined by the National Institutes of Health Stroke Scale (NIHSS). Brain CT findings including territory of infarct, cortical involvement and hemorrhagic transformation are investigated by reviewing the CT scans and recording the results in the questionnaire. Correlation of each mentioned factor with post-stroke epilepsy occurrence will be assessed using statistical methods. |
Countries
Iran
Outcome results
None listed