Low Flow Anesthesia
Conditions
Brief summary
This study aimed to compare the effects of sevoflurane and desflurane used in low-flow anesthesia on thiol-disulfide homeostasis of patients undergoing general anesthesia.
Detailed description
Fifty patients were included who were scheduled to undergo elective total thyroidectomy operation under general anesthesia. The patients were assigned to one of 2 groups. Group S was the low-flow sevoflurane anesthesia group and Group D was the low-flow desflurane group. Blood samples were collected to evaluate thiol disulfide homeostasis preoperatively and postoperatively.
Interventions
OTHERA 5 cc venous blood sample was obtained
A 5 cc venous blood sample was obtained just before anesthesia induction and at the end of surgery.
PROCEDURElow-flow anesthesia
Low-flow anesthesia, also known as inhalational anesthesia method, is a type of anesthesia that is performed using a semi-closed, rebreathing system containing at least 50% fresh gas. Generally, low-flow anesthesia is used in anesthesia practices because it reduces costs, prevents environmental pollution, increases the humidity of gases, and reduces heat loss. Another important benefit of low-flow is that it requires closer monitoring of patients, which allows for early detection of complications during general anesthesia, thus improving patient safety. Concerns about low-flow anesthesia being used infrequently in the past have been addressed by the introduction of modern anesthesia workstations with sophisticated monitoring and safety features, which have made low-flow anesthesia widely used in most centers.
Sponsors
University of Gaziantep
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients who were scheduled to undergo elective total thyroidectomy under general anesthesia
Exclusion criteria
* Patients with diabetes mellitus, alcohol or drug addiction, smoking habits, expected difficult intubation, morbid obesity, chronic obstructive pulmonary disease, cardiovascular disease and those in pregnancy or lactation period were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum thiol-disulfide homeostasis parameters measurement/ calculation | A 5 cc venous blood sample was obtained just before the anesthesia induction and at the end of surgery. | Serum thiol-disulfide homeostasis parameters were evaluated using an automated method (3). Homeostasis parameters include disulfide, native thiol (NT) and total thiol (TT) levels, and disulfide/TT, NT/TT, and disulfide/NT ratios. TT and NT levels were measured in μmol/L on a Beckman Coulter AU480 analyzer using a commercial kits (Rel Assay Diagnostics, Türkiye). The amount of disulfide was calculated using the formula ((TT-NT) /2). Then, ratios were calculated as percentages |
Countries
Turkey (Türkiye)
Outcome results
None listed