Cardiac Arrest (CA), Heart Arrest, In-Hospital Cardiac Arrest
Conditions
Keywords
prospective observational study, ventilation, manual ventilation, cardiac arrest, in-hospital cardiac arrest (IHCA), bag-valve-mask (BVM), tidal volume, ventilation rate, intra-arrest ventilation, cardiopulmonary ventilation (CPR), resuscitation, adult
Brief summary
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients. The main questions it aims to answer are: What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC? Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
Interventions
OTHERPositive pressure ventilation during cardiopulmonary resuscitation
The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.
Sponsors
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. In-hospital cardiac arrest 2. Age ≥ 18 years 3. \>1minute of recorded ventilation data
Exclusion criteria
1. Documented do-not-attempt cardiopulmonary resuscitation order 2. Invasive mechanical circulatory support at the time of the cardiac arrest
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fraction of patients with return of spontaneous circulation (ROSC) | ROSC is assessed immediately following cardiopulmonary resuscitation. | ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fraction of patients surviving until day 30 | Assessed at day 30 after cardiac arrest. | Patient survival for at least 30 days following cardiac arrest. |
Countries
Denmark, Norway
Contacts
CONTACTJohannes Wittig, MD
CONTACTKasper G Lauridsen, MD, PhD
PRINCIPAL_INVESTIGATORJohannes Wittig, MD
Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark
PRINCIPAL_INVESTIGATORKasper G Lauridsen, MD, PhD
Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;
Outcome results
None listed