Inflammatory Markers, Liver Enzymes
Conditions
Keywords
Alanine transaminase, Alkaline phosphatase, Postmenopausal obesity, C-reactive protein, Walking training, Erythrocyte sedimentation rate
Brief summary
The goal of this clinical trial is to investigate the impact of a walking training intervention program on liver enzymes and selected inflammatory markers in postmenopausal women with obesity. The main question it aims to answer is: Does walking training reduce the risk of liver disease by modulating hepatic-enzymes and selected inflammatory markers? Researchers will compare walking training intervention (designed to the experimental group) to non-training intervention (designed to the control group) to see if the training program works to improve liver health in obese postmenopausal women. Participants in the experimental (training) group will: underwent a moderate intensity intermittent walking training (MIWT) at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session. Participants in control group will : not perform any physical training and maintain their usual daily activities.
Detailed description
Postmenopausal obesity is an important public health problem accompanied by increased systemic inflammation that escalates the risk of liver disease. Exercise improved inflammatory and hepatic function. Moderate-intensity intermittent-walking-training (MIWT) is the most feasible for obese-postmenopausal-women. This study aimed to investigate whether MIWT could reduce the risk by modulating hepatic-enzymes and selected inflammatory markers. Thirty-six sedentary obese postmenopausal women (mean age 55.7±3.5) were randomly divided into two groups: training group (TG, n=18) and control group (CG, n=18). The TG underwent a MIWT at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session. Body composition, hepatic (alanine-transaminase (ALT), aspartate-transaminase (AST), alkaline-phosphatase, gamma-glutamyl-transferase (GGT) and serum-bilirubin\] and inflammatory markers \[C-reactive-protein (CRP), and erythrocyte-sedimentation-rate (ESR)) were evaluated at baseline and after 10-week of protocol.
Interventions
BEHAVIORALWalking training intervention
Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week.
Sponsors
Wissal Abassi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Women included are: * Postmenopausal (≥1 year of amenorrhea). * Obese (body mass index (BMI) ≥30 kg/m2). * Sedentary (\<120 min/week of low to moderate intensity physical activity at during the past 6 months). * Aged 50 to 60 years.
Exclusion criteria
* Suffering from any cardiovascular/renal/pulmonary/metabolic disease. * Being under menopausal hormone therapy. * Presenting any orthopedic limitations interfering the ability to perform the study intervention.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Erythrocyte sedimentation rate | At baseline and at week 11(after the ten weeks of the training intervention). | Erythrocyte-sedimentation-rate (ESR) are measured from a blood sample (5 ml). |
| Serum bilirubin | At baseline and at week 11(after the ten weeks of the training intervention). | Serum concentrations of bilirubin are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| C reactive protein | At baseline and at week 11(after the ten weeks of the training intervention). | Serum concentration of C-reactive-protein (CRP) are measured from a blood sample (5 ml). |
| Alanine transaminase | At baseline and at week 11(after the ten weeks of the training intervention). | Serum concentrations of alanine-transaminase (ALT) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| Aspartate transaminase | At baseline and at week 11(after the ten weeks of the training intervention). | Serum concentrations of aspartate-transaminase (AST),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| Alkaline phosphatase | At baseline and at week 11(after the ten weeks of the training intervention). | Serum concentrations of alkaline-phosphatase are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| Gamma glutamyl transferase | At baseline and at week 11(after the ten weeks of the training intervention) | Serum concentrations of gamma-glutamyl-transferase (GGT),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Aerobic capacity | At baseline and after ten weeks of the training intervention. | The 6-minute walk test was performed before and after the training intervention as an indicator of exercise capacity. |
| Body composition | At baseline and after ten weeks of the training intervention. | Body composition were determined, with barefoot and lightly dressed subjects, using a stadiometer (Holtain Ltd., UK) and an electronic scale (Tanita BC-533, Tokyo, Japan). |
Countries
Tunisia
Outcome results
None listed