Amyloid Angiopathy
Conditions
Keywords
Cerebral Amyloid Angiopathy
Brief summary
Ischaemic microangiopathic features have recently been incorporated into the criteria for cerebral amyloid angiopathy (CAA). ApoE genotyping (presence of the E4 allele) is routinely used to help determine the aetiology of a haemorrhagic microangiopathy found on MRI. Chronic ischaemic disease in CAA is characterised by the presence of : * multispot pattern on the FLAIR sequence * severe periventricular FLAIR hypersignals with posterior predominance The main aim of this study was therefore to analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected CAA based on ischaemic MRI involvement with a typical radiological pattern.
Interventions
None listed
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with ischaemic stroke (from causes other than CAA, as CAA is not a frequent cause of ischaemic stroke) with associated stigmata of microangiopathy on MRI that may suggest associated CAA. * Patients treated at Nîmes University Hospital
Exclusion criteria
* Patient refusing to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ApoE genotypage | baseline | To analyse the frequency of the presence of one (or two) E4 allele(s) on ApoE genotyping in patients with suspected AAC. Endpoint: presence of the E4 allele (Yes/No). |
Countries
France
Contacts
STUDY_DIRECTORAnissa MEGZARI
Centre Hospitalier Universitaire de Nīmes
Outcome results
None listed