Myocardial Injury
Conditions
Brief summary
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.
Detailed description
This study explored the important role of BMP6/SMAD pathway in myocardial/injury protection by observing the effects of different doses of opioids on myocardial injury indexes hs-cTnI and BMP-6 related indexes in patients undergoing lower extremity fracture surgery, as well as the changes of BMP6 expression in bone marrow tissue of fracture end. The relationship between different doses of opioids and BMP6 and cardiac adverse events provides a theoretical basis for clinical rational drug use.
Interventions
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
DRUGPlacebo
Placebo
Sponsors
Second Hospital of Shanxi Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* There were 160 patients aged 18-65 years and older who needed surgery for lower extremity fracture. * ASA grades I to III, gender is not limited.
Exclusion criteria
* Patients with acute myocardial infarction in the last 6 months, those with a history of heart failure, and those with elevated troponin levels before injury. * Old fracture * Stroke patients * Liver cirrhosis, kidney failure * Serious systemic infections, alcoholism, drug dependence * Pathological fracture * Use of glucocorticoids in the past one month * Diabetic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum BMP6 | Immediate postoperative measurement | Dose measurement of BMP6 in serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| one marrow tissue BMP6 | Immediate postoperative measurement | To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow tissue of fracture end |
Other
| Measure | Time frame | Description |
|---|---|---|
| Perioperative cardiac adverse events | Immediate postoperative measurement | To observe the effects of opioids and BMP6 on perioperative cardiovascular adverse events (ACVE) in patients with lower extremity fractures |
Countries
China
Contacts
Primary ContactJvan Wu, Docter
Outcome results
None listed