Skip to content

The Magnitude of Inter-limb Asymmetry and Its Assocation with Inter-limb Asymmetry in Distance Runners and Non-runners

Lower Limb Functional Asymmetry in Healthy Novice, Moderately and Highly-trained Distance Runners Versus Non-athletes

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06808399
Acronym
ASYMRUN
Enrollment
72
Registered
2025-02-05
Start date
2023-01-01
Completion date
2025-06-01
Last updated
2025-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

Distance running is one of the most popular and most accessible ways to engage in physical activity. Although distance running offers numerous health-related benefits and protects against noncommunicable diseases (e.g., type 2 diabetic, obesity, hypertension), research has indicated a high prevalence of running-related injuries with a more pronounced incidence among novice runners (i.e., 17.8 injuries per 1000h) compared to their highly trained peers (i.e., 7.2 injuries per 1000h). Interlimb asymmetry has previously been related to higher injury risk as well as to impaired sports performances. Nevertheless, to date, research on the degree and evolution of functional asymmetry (e.g., unequal strength between limbs) in distance runners is scarce and the role of functional asymmetries in running performance and running-related injuries remains unclear. Moreover, and despite the great number of unilateral tests available in the literature, there currently exists no reliable and run-specific field-based test battery to examine the degree of lower limb asymmetry in distance runners. Therefore, this study aims to assess the test-retest, intra- and inter-rater reliability of a newly created running-specific field-based test battery to assess the presence and degree of functional lower limb asymmetry among novice, moderatly and highly trained distance runners as well as a control group of non-athletes. The second objective is to assess the association between inter-limb asymmetry and running performance.

Interventions

None listed

Sponsors

Vrije Universiteit Brussel
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* • Being aged between 20 and 50 years at Tfamiliarization * Being free from any medical attention injury (i.e., injury that results in a participant receiving medical attention) for at least 6 months upon Tfamiliarization * Speaking Dutch, French or English * Highly trained distance runners: * Running at least 150km per month for at least 3 months Moderately-trained runners: * Running between 40 - 150 km per month for at least 6 months \- Novice distance runners: * Running not more than 10km per week for the past 12 months \- Control group of non-athletes * Performing \<75min of systematic moderate to vigorous-intensity physical activity per week and having no experience in systematic (un)structured running activities for the past 5 years

Exclusion criteria

* • Being younger than 20 years or older than 50 years at Tfamiliarization * Any known relevant medical history or current condition (e.g., neurological diseases, inner ear diseases) that could affect the performance of the functional tests (e.g., balance in repeated hop tests) * Participants that have undergone a surgery at lower limb level during the past 6 months * Medication or drug use (e.g., blood pressure medicines)that could affect the performance of the functional tests (e.g., balance in repeated hop tests) * Participants performing more than two hours per week of unilateral sports (e.g., tennis or soccer)

Design outcomes

Primary

MeasureTime frameDescription
Stride lengthThis test will be carried out on the third test occasion (four weeks after baseline).Measured using an Optojump device.
Cooper testThis test will be carried out on the second test occasion (two weeks after baseline).Maximal distance covered in 12 minutes.
Training volumeBaselineSurveyed with an online questionnaire and quantified in hours/week (per sport performed).
Contact time while runningThis test will be carried out on the third test occasion (four weeks after baseline).Measures with an Optojump device
Flight time while runningThis test will be carried out on the third test occasion (four weeks after baseline).Measured using an Optojump device.
Lean massBaselineMeasured using dual-energy X-ray absorptiometry.
Fat massBaselineMeasured using dual-energy X-ray absorptiometry.
Bone mineral densityBaselineMeasured using dual-energy X-ray absorptiometry.
Phase angleBaselineMeasured using bioelectrical impedance analysis.
Total segmental waterBaselineMeasured using bioelectrical impedance analysis.
Extracellular waterBaselineMeasured using bioelectrical impedance analysis.
5 repeated vertical hop test.3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using an Optojump device
5 repeated horizontal hop test3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using an Optojump device
ankle dorsiflexion range of motion3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.The maximal dorsiflexion range of motion (cm from a wall) will be measured with tape measure.
Side bridge endurance test3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.The side bridge endurance test will be carried out in which, the participants will lie on one side of the body fully extended (i.e., hip and torso at 0°) in a plank position with the feet elevated on a 15-cm step and with the superior feet placed in front. The participants will be instructed to lift the hips until the body is in straight position with the arms folded across the chest. The time until a drop (lasting more than 3s) of the hips from the optimal position will manually be recorded. To control for a full range of motion upon the execution of this muscle capacity tests, a reference dowel will be used to indiciate the desired range of motion.
Hip adduction strength3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured with a handheld dynamometer.
Hip abduction strength3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using a hand-held dynamometer.
Knee extension strength3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using a hand-held dynamometer.
Knee flexion strength3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using a hand-held dynamometer.
Ankle dorsiflexion strength3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using a hand-held dynamometer.
Ankle plantar flexion strength3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.Measured using a hand-held dynamometer.

Secondary

MeasureTime frameDescription
HeightBaseline
Leg lengthBaselineMeasured using dual-energy X-ray absorptiometry and a tape measure.
Bone mineral contentBaselineMeasured busing dual-energy X-ray absorptiometry.
WeightBaseline

Countries

Belgium

Contacts

Primary ContactJoachim D'Hondt
Joachim.dhondt@vub.be+32 (0) 629 27 35

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 10, 2026