Effects of Dark Chocolate on the Risk Factors of Cardiovascular Diseases

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06808282

Enrollment

Registered

2025-02-05

Start date

2011-04-01

Completion date

2026-12-31

Last updated

2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Brief summary

Cardiovascular disease (CVD) is the number one cause of death in the US. Epidemiologic evidence supports that antioxidant-rich diets promote health and attenuate or delay the onset of CVD. Cocoa and chocolate products have among the highest antioxidant concentrations compared to other antioxidant food sources. The objective of this study is to examine the effects of regular dark chocolate, bloomed dark chocolate, and white chocolate on cardiovascular health markers.

Interventions

OTHERWhite chocolate

To determine the effects of white chocolate consumption on risk factors of cardiovascular diseases

OTHERDark chocolate

To determine the effects of dark chocolate consumption on risk factors of cardiovascular diseases

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Generally healthy subjects

Exclusion criteria

* Smoker * Pregnant woman * Lactose intolerance * Required dietary supplement use * Required medication of metabolic disorders * Allergy to cacao

Design outcomes

Primary

Measure	Time frame	Description
Change of systolic and diastolic blood pressure	Baseline and Day 15	Change of systolic and diastolic blood pressure will be determined to examine effects of dark chocolate consumption vs white chocolate.
Change of skin blood flow level	Baseline and Day 15	Change of skin blood flow level will be determined using Laser Doppler Flowmetry to examine effects of dark chocolate consumption vs white chocolate. Laser Doppler flowmetry is an optical technology widely used in research to measure blood flow. It is a non-invasive, painless technique for studying microcirculatory changes in tissue.
Change of HDL cholesterol level	Baseline and Day 15	Change of blood cholesterol level will be determined to examine effects of dark chocolate consumption vs white chocolate.
Change of antioxidant levels	Baseline and Day 15	Change of antioxidant levels will be determined to examine effects of dark chocolate consumption vs white chocolate.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026