Depression - Major Depressive Disorder, Suicide
Conditions
Keywords
suicide, depression, major depressive disorder, ketamine
Brief summary
As part of the usual clinical activity of the Emergency and Post-Emergency Psychiatric Department, IV ketamine is used to treat suicidal crises in depressed patients hospitalized as an add-on to the treatment of depression. This infusion can be repeated. Patients are systematically reassessed twice in the month following the last infusion, to ensure that the suicidal crisis is progressing. Psychometric assessments are part of routine care, to ensure systematic evaluation of psychopathology, intensity of depression and suicidality. Therefore existing data were re-used from the medical records of patients who had received ketamine infusions to assess the effect of ketamine on suicidal ideation and behaviour.
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients treated with IV ketamine in the Psychiatric Emergency and Post-Emergency Department (University Hospital, Montpellier) in context of suicidal crisis * over 18 y.o
Exclusion criteria
* Opposition to data use * Subject deprived of liberty (by judicial or administrative decision) * Subject protected by law (guardianship or curatorship) * Subject not affiliated to a social security system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| suicidal ideation at 7 days after IV ketamine administration | 7 days | evolution of suicidal ideation at 7 days after IV ketamine administration in the context of a suicidal crisis using severity of suicidal ideation according to C-SSRS (COLUMBIA-SUICIDE SEVERITY RATING SCALE) The ideation severity subscale ranges from 1 to 5 (higher score indicating more severe ideation). The ideation intensity subscale includes 5 questions each ranging from 1 to 5 (higher score indication more intense ideation). The suicidal behavior subscale includes 4 yes/no questions. The suicidal behavior lethality subscale inquires about the level of actual or potential medical damage. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Severity of depressive symptomatology at 7 days | 7 days | change in depressive symptomatology at 1 week using Montgomery-Åsberg Depression Rating Scale (MADRS) The scale consists of 10 items rated from 0 to 6. A score between 0 and 6 indicates euthymia, a score between 7 and 19 mild depression, a score between 20 and 34 moderate depression and a score above 34 severe depression. |
| Severity of depressive symptomatology at 1 month | 1 month | change in depressive symptomatology at 1 week using Montgomery-Åsberg Depression Rating Scale (MADRS) The scale consists of 10 items rated from 0 to 6. A score between 0 and 6 indicates euthymia, a score between 7 and 19 mild depression, a score between 20 and 34 moderate depression and a score above 34 severe depression. |
| suicidal ideation at 7 days after IV ketamine | 7 days | number of hospitalization or ER visit for suicidal ideation |
| suicidal ideation at 1 month after IV ketamine administration | 1 month | evolution of suicidal ideation at 7 days after IV ketamine administration in the context of a suicidal crisis using severity of suicidal ideation according to C-SSRS (COLUMBIA-SUICIDE SEVERITY RATING SCALE) The ideation severity subscale ranges from 1 to 5 (higher score indicating more severe ideation). The ideation intensity subscale includes 5 questions each ranging from 1 to 5 (higher score indication more intense ideation). The suicidal behavior subscale includes 4 yes/no questions. The suicidal behavior lethality subscale inquires about the level of actual or potential medical damage. |
| suicidal behavior at 3 months after IV ketamine | 3 months | number of suicide attempts (confirmed, aborted, interrupted) |
| suicidal ideation at 1 month after IV ketamine | 1 month | number of hospitalization or ER visit for suicidal ideation |
| suicidal ideation at 3 months after IV ketamine | 3 months | number of hospitalization or ER visit for suicidal ideation |
| suicidal behavior at 1 month after IV ketamine | 1 month | number of suicide attempts (confirmed, aborted, interrupted) |
Countries
France
Outcome results
None listed