Incidence of Fragility Fractures and Osteoporosis Screening in Chronic Stroke Patients

Incidence of Fragility Fractures and Osteoporosis Screening in Chronic Stroke Patients: a Prospective Observational Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06804252

Enrollment

Registered

2025-02-03

Start date

2024-12-10

Completion date

2025-08-31

Last updated

2025-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Stroke, Fragility Fractures, Osteoporosis

Keywords

chronic stroke, osteoporis, fragility fractures, Hip fractures, Stroke risk factors, Bone density (DEXA), bone, Bone mineral density, Bone metabolism, Bone health, Bone health intervention, Post-stroke, Bone density screening

Brief summary

Stroke is a known risk factor for the development of osteoporosis, leading to an increased risk of falls and fractures. Several international studies have associated stroke with hip fractures, showing an odds ratio ranging between 1.5 and 4. The literature frequently indicates a lack of management for bone metabolism in patients following cerebrovascular events. This study aims to evaluate the incidence of osteoporosis and fragility fractures in patients with chronic stroke. A secondary aim is to assess whether patients have been adequately screened for bone metabolism following a cerebrovascular event. This study is designed as a prospective observational study. Patients aged over 65 years with chronic stroke are assessed at the U.O.C. of Functional Recovery and Rehabilitation at A.O.U.P. P. Giaccone, Palermo. During the assessment, clinical and demographic data are collected, including details of the cerebrovascular event (location, hemorrhagic/ischemic, date), pre-event and post-event disability/autonomy (Rankin scale), presence of fractures (location and date) in the patient's medical history (pre and post-event), femoral and lumbar DEXA for osteoporosis evaluation, and DeFRA for assessing the 10-year risk of fragility fractures.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients aged 65 years and older * Diagnosed with chronic stroke * Able to provide informed consent * Willing to participate in follow-up assessments * Stable medical condition that allows participation in the study

Exclusion criteria

* Patients with acute stroke * Severe cognitive impairment that prevents informed consent * Other major illnesses affecting bone metabolism (e.g., severe renal disease) * Patients already undergoing treatment for osteoporosis * Patients with conditions that contraindicate DEXA scan

Design outcomes

Primary

Measure	Time frame	Description
Evaluating the Incidence of Osteoporosis and Fragility Fractures in Chronic Stroke Patients	From enrollment to the end of treatment at 6 months	The primary objective of this study is to evaluate the incidence of osteoporosis and fragility fractures in patients with chronic stroke.

Secondary

Measure	Time frame	Description
Proper screening for bone metabolism in patients after cerebrovascular event	From enrollment to the end of treatment at 6 months	Number of patients who were properly screened for bone metabolism after the cerebrovascular event.

Countries

Italy

Outcome results