Atrial Fibrillation (AF)
Conditions
Keywords
Atrial Fibrillation, Electrocardiographic Imaging, Noninvasive Mapping, Surgical Ablation
Brief summary
The purpose of this study is to assess the electrophysiological mechanism of atrial fibrillation by means of a beat-to-beat noninvasive 3D mapping method in patients with concomitant persistent and long-standing persistent atrial fibrillation undergoing surgical ablation.
Interventions
Electrocardiographic imaging is an electrophysiological mapping technique which is used to noninvasively map cardiac arrhythmias.
Sponsors
Medical University of Vienna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* legal age (18-90a) * life expectancy \> 2 years * patients suffering from persistent and long standing atrial fibrillation * scheduled for concomitant surgical ablation * possibility to follow-up * given informed consent
Exclusion criteria
* vulnerable patient groups * pregnancy * any previous surgical ablation * acute surgical indications * any physical condition that leads to a life expectancy of less than two years * any contraindication to the treatments necessary for the trial's conduction as e.g. * known allergic reaction to contrast agent * known allergic reaction to antiarrhythmic drugs * claustrophobia or anxiety in small spaces * severe renal impairment * unmanageable hyperthyroidism * participation in any other clinical trial that either excludes enrolment or may be a confounding factor to results * voluntary retention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The patients electrophysiological mapping results acquired with ECGI will be analyzed: Number and distribution of rotor and focal activities will be measured. | Prior to the planned procedure. | The primary objective of this study is to measure the patients electrophysiological mapping results acquired with ECGI, namely the number and distribution of focal and rotor activities. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Freedom from AF during 12 and 24 months of follow-up. | From surgery until 24 months after the procedure. | A pre-specified outcome measure is to measure freedom from AF during 12 and 24 months of follow-up. The impact of the preoperative mapping results and the applied respective ablation technique will be analyzed. |
Countries
Austria
Outcome results
None listed