Type 1 Diabetes
Conditions
Keywords
adolescents, type 1 diabetes, glycemic regulation, circadian rhythm
Brief summary
Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes
Detailed description
Single-center, randomized, controlled study in adolescents living with type 1 diabetes. This study aims to evaluate the effect of exercise timing (morning vs. afternoon) and exercise type (continuous vs. intermittent) on blood glucose levels during and after exercise, as well as to assess the effect of exercise timing (morning vs. afternoon) and type of exercise (continuous vs. intermittent) on blood glucose during and after exercise
Interventions
OTHERphysical test
continuous and intermittent exercise on cycloergometer
Sponsors
Lille University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Masking description
It is not possible to do a trial in blind or double blind because the moment of the day and the exercice modality can not be hidden, however the results analysis will be assessed in blind
Intervention model description
4 randomized handovers performed (on different days with meal/snack)previous standardized: * Continuous exercise on ergocycle in the morning * Continuous exercise on ergocycle in the afternoon * Intermittent exercise on ergocycle in the morning * Intermittent exercice on ergocycle in the afternoon
Eligibility
Sex/Gender
ALL
Age
10 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Children and adolescents aged 10 to 16; * Living with type 1 diabetes for at least 1 year with HbA1c less than or equal to 12%; * Socially insured ; * Having given their written consent to participate in the research, as well as that of their legal guardians; * Willing to comply with all research procedures and duration.
Exclusion criteria
* Clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate less than 40 ml/min), neuropathy or severe proliferative retinopathy as assessed by the investigator; * Recent acute macrovascular event (\< 3 months), e.g. acute coronary syndrome or cardiac surgery; * Abnormal blood picture and/or anemia; * Current pregnancy; * Other serious medical condition likely to interfere with study participation or ability to complete exercise periods in the judgment of the investigator (e.g., orthopedic limitation); * Inability to receive informed information; * Inability to participate in the entire study; * Lack of social security coverage; * Refusal to sign the consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of glycemic variation between the 4 conditions | 1 year 10 months september 2026 | Observation of time in target, time in hypoglycemia and time in hyperglycemia |
Countries
France
Outcome results
None listed